Drimane Sesquiterpene-Conjugated Amino Acids from a Marine Isolate of the Fungus Talaromyces minioluteus (Penicillium Minioluteum).
Mar Drugs
; 13(6): 3567-80, 2015 Jun 05.
Article
em En
| MEDLINE
| ID: mdl-26058010
ABSTRACT
Four new sesquiterpene lactones (3, 4, 6 and 7) and three known compounds, purpuride (1), berkedrimane B (2) and purpuride B (5), were isolated from the marine fungus, Talaromyces minioluteus (Penicillium minioluteum). New compounds were drimane sesquiterpenes conjugated with N-acetyl-l-valine, and their structures were elucidated by analysis of spectroscopic data, as well as by single crystal X-ray analysis. The isolated compounds could not inhibit the apoptosis-regulating enzyme, caspase-3, while three of the compounds (2, 3 and 7) exhibited weak cytotoxic activity.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Penicillium
/
Sesquiterpenos
/
Talaromyces
/
Lactonas
Limite:
Humans
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article