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Transmitted Extended-Spectrum Extensively Drug-Resistant Tuberculosis in Beijing, China, with Discordant Whole-Genome Sequencing Analysis Results.
Li, Hao; Kayani, Masood ur Rehman; Gu, Yunting; Wang, Xiaobo; Zhu, Ting; Duan, Hongfei; Ma, Yifeng; Huang, Hairong; Javid, Babak.
Afiliação
  • Li H; Collaborative Innovation Centre for Diagnosis and Treatment of Infectious Diseases, School of Medicine, Tsinghua University, Beijing, China.
  • Kayani Mu; Collaborative Innovation Centre for the Diagnosis and Treatment of Infectious Diseases, School of Life Sciences, Tsinghua University, Beijing, China.
  • Gu Y; National Clinical Laboratory on Tuberculosis, Beijing Tuberculosis and Thoracic Tumor Institute, Beijing Chest Hospital, Capital Medical University, Beijing, China.
  • Wang X; National Clinical Laboratory on Tuberculosis, Beijing Tuberculosis and Thoracic Tumor Institute, Beijing Chest Hospital, Capital Medical University, Beijing, China.
  • Zhu T; Collaborative Innovation Centre for the Diagnosis and Treatment of Infectious Diseases, School of Life Sciences, Tsinghua University, Beijing, China.
  • Duan H; Department of Tuberculosis, Beijing Tuberculosis and Thoracic Tumor Institute, Beijing Chest Hospital, Capital Medical University, Beijing, China.
  • Ma Y; National Clinical Laboratory on Tuberculosis, Beijing Tuberculosis and Thoracic Tumor Institute, Beijing Chest Hospital, Capital Medical University, Beijing, China.
  • Huang H; National Clinical Laboratory on Tuberculosis, Beijing Tuberculosis and Thoracic Tumor Institute, Beijing Chest Hospital, Capital Medical University, Beijing, China huanghairong@tb123.org bjavid@gmail.com.
  • Javid B; Collaborative Innovation Centre for Diagnosis and Treatment of Infectious Diseases, School of Medicine, Tsinghua University, Beijing, China huanghairong@tb123.org bjavid@gmail.com.
J Clin Microbiol ; 53(8): 2781-4, 2015 Aug.
Article em En | MEDLINE | ID: mdl-26063862
ABSTRACT
Drug resistance to tuberculosis remains a major public health threat. Here, we report two cases of extended-spectrum extensively drug-resistant (XXDR) tuberculosis showing resistance to most first- and second-line agents. The results of a correlation of whole-genome sequencing (WGS) and phenotypic testing were discordant, suggesting that overreliance on WGS may miss clinically relevant resistance in extensively drug-resistant disease.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Genoma Bacteriano / Tuberculose Extensivamente Resistente a Medicamentos / Mycobacterium tuberculosis Limite: Adult / Humans / Male / Middle aged País como assunto: Asia Idioma: En Ano de publicação: 2015 Tipo de documento: Article
Texto completo
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Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Genoma Bacteriano / Tuberculose Extensivamente Resistente a Medicamentos / Mycobacterium tuberculosis Limite: Adult / Humans / Male / Middle aged País como assunto: Asia Idioma: En Ano de publicação: 2015 Tipo de documento: Article