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TISSUE REGENERATION. Inhibition of the prostaglandin-degrading enzyme 15-PGDH potentiates tissue regeneration.
Zhang, Yongyou; Desai, Amar; Yang, Sung Yeun; Bae, Ki Beom; Antczak, Monika I; Fink, Stephen P; Tiwari, Shruti; Willis, Joseph E; Williams, Noelle S; Dawson, Dawn M; Wald, David; Chen, Wei-Dong; Wang, Zhenghe; Kasturi, Lakshmi; Larusch, Gretchen A; He, Lucy; Cominelli, Fabio; Di Martino, Luca; Djuric, Zora; Milne, Ginger L; Chance, Mark; Sanabria, Juan; Dealwis, Chris; Mikkola, Debra; Naidoo, Jacinth; Wei, Shuguang; Tai, Hsin-Hsiung; Gerson, Stanton L; Ready, Joseph M; Posner, Bruce; Willson, James K V; Markowitz, Sanford D.
Afiliação
  • Zhang Y; Department of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.
  • Desai A; Department of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.
  • Yang SY; Department of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA. Department of Gastroenterology, Haeundae Paik Hospital, Inje University, Busan 612896, South Korea.
  • Bae KB; Department of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA. Department of Surgery, Busan Paik Hospital, and Paik Institute of Clinical Research and Ocular Neovascular Research Center, Inje University, Busan, South Korea.
  • Antczak MI; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
  • Fink SP; Department of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.
  • Tiwari S; Department of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA. Case Medical Center, University Hospitals of Cleveland, Cleveland, OH 44106, USA.
  • Willis JE; Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH 44106, USA. Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA. Case Medical Center, University Hospitals of Cleveland, Cleveland, OH 44106, USA.
  • Williams NS; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
  • Dawson DM; Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH 44106, USA. Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA.
  • Wald D; Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH 44106, USA. Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA. Case Medical Center, University Hospitals of Cleveland, Cleveland, OH 44106, USA.
  • Chen WD; Department of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.
  • Wang Z; Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH 44106, USA. Department of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, OH 44106, USA.
  • Kasturi L; Department of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.
  • Larusch GA; Department of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.
  • He L; Department of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.
  • Cominelli F; Department of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA. Case Medical Center, University Hospitals of Cleveland, Cleveland, OH 44106, USA.
  • Di Martino L; Department of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.
  • Djuric Z; Department of Family Medicine, University of Michigan, Ann Arbor MI 48109, USA.
  • Milne GL; Department of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA.
  • Chance M; Proteomics Center, Case Western Reserve University, Cleveland, OH 44106, USA.
  • Sanabria J; Department of Surgery, Case Western Reserve University, Cleveland, OH 44106, USA. Case Medical Center, University Hospitals of Cleveland, Cleveland, OH 44106, USA.
  • Dealwis C; Department of Pharmacology, Case Western Reserve University, Cleveland, OH 44106, USA.
  • Mikkola D; Department of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.
  • Naidoo J; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
  • Wei S; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
  • Tai HH; College of Pharmacy, University of Kentucky, Lexington, KY 40536, USA.
  • Gerson SL; Department of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA. Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH 44106, USA. Case Medical Center, University Hospitals of Cleveland, Cleveland, OH 44106, USA. sxm10@cwru.edu james.willson@utsouthwester
  • Ready JM; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Simmons Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. sxm10@cwru.edu james.willson@utsouthwestern.edu slg5@cwru.edu joseph.ready@utsouthwestern.edu bruce.posne
  • Posner B; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Simmons Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. sxm10@cwru.edu james.willson@utsouthwestern.edu slg5@cwru.edu joseph.ready@utsouthwestern.edu bruce.posne
  • Willson JK; Simmons Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. sxm10@cwru.edu james.willson@utsouthwestern.edu slg5@cwru.edu joseph.ready@utsouthwestern.edu bruce.posner@utsouthwestern.edu.
  • Markowitz SD; Department of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA. Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH 44106, USA. Case Medical Center, University Hospitals of Cleveland, Cleveland, OH 44106, USA. sxm10@cwru.edu james.willson@utsouthwester
Science ; 348(6240): aaa2340, 2015 Jun 12.
Article em En | MEDLINE | ID: mdl-26068857
Agents that promote tissue regeneration could be beneficial in a variety of clinical settings, such as stimulating recovery of the hematopoietic system after bone marrow transplantation. Prostaglandin PGE2, a lipid signaling molecule that supports expansion of several types of tissue stem cells, is a candidate therapeutic target for promoting tissue regeneration in vivo. Here, we show that inhibition of 15-hydroxyprostaglandin dehydrogenase (15-PGDH), a prostaglandin-degrading enzyme, potentiates tissue regeneration in multiple organs in mice. In a chemical screen, we identify a small-molecule inhibitor of 15-PGDH (SW033291) that increases prostaglandin PGE2 levels in bone marrow and other tissues. SW033291 accelerates hematopoietic recovery in mice receiving a bone marrow transplant. The same compound also promotes tissue regeneration in mouse models of colon and liver injury. Tissues from 15-PGDH knockout mice demonstrate similar increased regenerative capacity. Thus, 15-PGDH inhibition may be a valuable therapeutic strategy for tissue regeneration in diverse clinical contexts.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Regeneração / Hidroxiprostaglandina Desidrogenases / Prostaglandinas Limite: Animals Idioma: En Ano de publicação: 2015 Tipo de documento: Article
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Regeneração / Hidroxiprostaglandina Desidrogenases / Prostaglandinas Limite: Animals Idioma: En Ano de publicação: 2015 Tipo de documento: Article