A double bond-conjugated dimethylnitrobenzene-type photolabile nitric oxide donor with improved two-photon cross section.
Bioorg Med Chem Lett
; 25(16): 3172-5, 2015 Aug 15.
Article
em En
| MEDLINE
| ID: mdl-26073004
ABSTRACT
Photocontrollable NO donors enable precise spatiotemporal release of NO under physiological conditions. We designed and synthesized a novel dimethylnitrobenzene-type NO donor, Flu-DNB-DB, which contains a carbon-carbon double bond in place of the amide bond of previously reported Flu-DNB. Flu-DNB-DB releases NO in response to one-photon activation in the blue wavelength region, and shows a greatly increased two-photon cross-section (δu) at 720 nm (Flu-DNB 0.12 GM, Flu-DNB-DB 0.98 GM). We show that Flu-DNB-DB enables precisely controlled intracellular release of NO in response to 950 nm pulse laser irradiation for as little as 1s. This near-infrared-light-controllable NO source should be a valuable tool for studies on the biological roles of NO.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Doadores de Óxido Nítrico
/
Nitrobenzenos
Limite:
Humans
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article