Small-molecule inhibitors targeting the DNA-binding domain of STAT3 suppress tumor growth, metastasis and STAT3 target gene expression in vivo.

Huang, W; Dong, Z; Chen, Y; Wang, F; Wang, C J; Peng, H; He, Y; Hangoc, G; Pollok, K; Sandusky, G; Fu, X-Y; Broxmeyer, H E; Zhang, Z-Y; Liu, J-Y; Zhang, J-T

Huang, W; Dong, Z; Chen, Y; Wang, F; Wang, C J; Peng, H; He, Y; Hangoc, G; Pollok, K; Sandusky, G; Fu, X-Y; Broxmeyer, H E; Zhang, Z-Y; Liu, J-Y; Zhang, J-T.

Afiliação

Huang W; Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, IN, USA.
Dong Z; Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, IN, USA.
Chen Y; Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, IN, USA.
Wang F; Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, IN, USA.
Wang CJ; Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, IN, USA.
Peng H; Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, IN, USA.
He Y; Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, USA.
Hangoc G; Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN, USA.
Pollok K; Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, IN, USA.
Sandusky G; Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, USA.
Fu XY; IU Simon Cancer Center, Indiana University School of Medicine, Indianapolis, IN, USA.
Broxmeyer HE; IU Simon Cancer Center, Indiana University School of Medicine, Indianapolis, IN, USA.
Zhang ZY; Department of Pathology and Molecular Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.
Liu JY; Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN, USA.
Zhang JT; IU Simon Cancer Center, Indiana University School of Medicine, Indianapolis, IN, USA.

Oncogene ; 35(6): 783-92, 2016 Feb 11.

Article em En | MEDLINE | ID: mdl-26073084

Assuntos

Antineoplásicos/farmacologia; Proliferação de Células/efeitos dos fármacos; Neoplasias/patologia; Domínios e Motivos de Interação entre Proteínas/efeitos dos fármacos; Fator de Transcrição STAT3/antagonistas & inibidores; Fator de Transcrição STAT3/genética; Animais; Células Cultivadas; DNA/metabolismo; Regulação Neoplásica da Expressão Gênica/efeitos dos fármacos; Humanos; Masculino; Camundongos; Camundongos Endogâmicos C57BL; Camundongos Endogâmicos NOD; Camundongos Knockout; Camundongos SCID; Terapia de Alvo Molecular; Metástase Neoplásica; Neoplasias/genética; Fator de Transcrição STAT3/química; Fator de Transcrição STAT3/metabolismo; Carga Tumoral/efeitos dos fármacos; Ensaios Antitumorais Modelo de Xenoenxerto

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proliferação de Células / Fator de Transcrição STAT3 / Domínios e Motivos de Interação entre Proteínas / Neoplasias / Antineoplásicos Tipo de estudo: Prognostic_studies Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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