Mechanisms of activation of nucleus accumbens neurons by cocaine via sigma-1 receptor-inositol 1,4,5-trisphosphate-transient receptor potential canonical channel pathways.

Barr, Jeffrey L; Deliu, Elena; Brailoiu, G Cristina; Zhao, Pingwei; Yan, Guang; Abood, Mary E; Unterwald, Ellen M; Brailoiu, Eugen

Barr, Jeffrey L; Deliu, Elena; Brailoiu, G Cristina; Zhao, Pingwei; Yan, Guang; Abood, Mary E; Unterwald, Ellen M; Brailoiu, Eugen.

Afiliação

Barr JL; Center for Substance Abuse Research, Temple University School of Medicine, Philadelphia, PA 19140, USA; Department of Pharmacology, Temple University School of Medicine, Philadelphia, PA 19140, USA.
Deliu E; Center for Substance Abuse Research, Temple University School of Medicine, Philadelphia, PA 19140, USA.
Brailoiu GC; Department of Pharmaceutical Sciences, Thomas Jefferson University, Jefferson School of Pharmacy, Philadelphia, PA 19107, USA.
Zhao P; Center for Substance Abuse Research, Temple University School of Medicine, Philadelphia, PA 19140, USA.
Yan G; Department of Pharmaceutical Sciences, Thomas Jefferson University, Jefferson School of Pharmacy, Philadelphia, PA 19107, USA.
Abood ME; Center for Substance Abuse Research, Temple University School of Medicine, Philadelphia, PA 19140, USA; Department of Anatomy and Cell Biology, Temple University School of Medicine, Philadelphia, PA 19140, USA.
Unterwald EM; Center for Substance Abuse Research, Temple University School of Medicine, Philadelphia, PA 19140, USA; Department of Pharmacology, Temple University School of Medicine, Philadelphia, PA 19140, USA. Electronic address: ellen.unterwald@temple.edu.
Brailoiu E; Center for Substance Abuse Research, Temple University School of Medicine, Philadelphia, PA 19140, USA. Electronic address: ebrailou@temple.edu.

Cell Calcium ; 58(2): 196-207, 2015 Aug.

Article em En | MEDLINE | ID: mdl-26077147

Assuntos

Cocaína/farmacologia; Receptores de Inositol 1,4,5-Trifosfato/metabolismo; Neurônios/efeitos dos fármacos; Núcleo Accumbens/citologia; Receptores sigma/metabolismo; Trifosfato de Adenosina/farmacologia; Animais; Comportamento Animal/efeitos dos fármacos; Cálcio/metabolismo; Sinalização do Cálcio/efeitos dos fármacos; Células Cultivadas; Retículo Endoplasmático/metabolismo; Imidazóis/farmacologia; Inositol 1,4,5-Trifosfato/farmacologia; Locomoção/efeitos dos fármacos; Masculino; Potenciais da Membrana/efeitos dos fármacos; Neurônios/citologia; Neurônios/metabolismo; Ratos; Ratos Sprague-Dawley; Canais de Cátion TRPC/metabolismo; Receptor Sigma-1

Palavras-chave

Calcium; Endoplasmic reticulum; Imaging; Nucleus accumbens; Sigma receptors; Transient receptor potential channels

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Receptores sigma / Cocaína / Receptores de Inositol 1,4,5-Trifosfato / Neurônios / Núcleo Accumbens Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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