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Freezing the Bioactive Conformation to Boost Potency: The Identification of BAY 85-8501, a Selective and Potent Inhibitor of Human Neutrophil Elastase for Pulmonary Diseases.
von Nussbaum, Franz; Li, Volkhart M-J; Allerheiligen, Swen; Anlauf, Sonja; Bärfacker, Lars; Bechem, Martin; Delbeck, Martina; Fitzgerald, Mary F; Gerisch, Michael; Gielen-Haertwig, Heike; Haning, Helmut; Karthaus, Dagmar; Lang, Dieter; Lustig, Klemens; Meibom, Daniel; Mittendorf, Joachim; Rosentreter, Ulrich; Schäfer, Martina; Schäfer, Stefan; Schamberger, Jens; Telan, Leila A; Tersteegen, Adrian.
Afiliação
  • von Nussbaum F; Medicinal Chemistry Berlin, Bayer HealthCare AG, 13353 Berlin (Germany). franz.nussbaum@bayer.com.
  • Li VM; Lead Discovery Wuppertal, Bayer HealthCare AG, 42096 Wuppertal (Germany). volkhart.li@bayer.com.
  • Allerheiligen S; Medicinal Chemistry Wuppertal, Bayer HealthCare AG, 42096 Wuppertal (Germany).
  • Anlauf S; Medicinal Chemistry Wuppertal, Bayer HealthCare AG, 42096 Wuppertal (Germany).
  • Bärfacker L; Medicinal Chemistry Wuppertal, Bayer HealthCare AG, 42096 Wuppertal (Germany).
  • Bechem M; Department of Cardiology Research Wuppertal, Bayer HealthCare AG, 42096 Wuppertal (Germany).
  • Delbeck M; Department of Cardiology Research Wuppertal, Bayer HealthCare AG, 42096 Wuppertal (Germany).
  • Fitzgerald MF; COPD Research, Bayer Healthcare AG, Slough SL2 4LY, Berkshire (UK).
  • Gerisch M; DMPK Wuppertal, Bayer HealthCare AG, 42096 Wuppertal (Germany).
  • Gielen-Haertwig H; Medicinal Chemistry Wuppertal, Bayer HealthCare AG, 42096 Wuppertal (Germany).
  • Haning H; Medicinal Chemistry Wuppertal, Bayer HealthCare AG, 42096 Wuppertal (Germany).
  • Karthaus D; Medicinal Chemistry Wuppertal, Bayer HealthCare AG, 42096 Wuppertal (Germany).
  • Lang D; DMPK Wuppertal, Bayer HealthCare AG, 42096 Wuppertal (Germany).
  • Lustig K; DMPK Wuppertal, Bayer HealthCare AG, 42096 Wuppertal (Germany).
  • Meibom D; Medicinal Chemistry Wuppertal, Bayer HealthCare AG, 42096 Wuppertal (Germany).
  • Mittendorf J; Medicinal Chemistry Wuppertal, Bayer HealthCare AG, 42096 Wuppertal (Germany).
  • Rosentreter U; Medicinal Chemistry Wuppertal, Bayer HealthCare AG, 42096 Wuppertal (Germany).
  • Schäfer M; Lead Discovery, Structural Biology Berlin, Bayer HealthCare AG, 13353 Berlin (Germany).
  • Schäfer S; Department of Cardiology Research Wuppertal, Bayer HealthCare AG, 42096 Wuppertal (Germany).
  • Schamberger J; Medicinal Chemistry Wuppertal, Bayer HealthCare AG, 42096 Wuppertal (Germany).
  • Telan LA; Medicinal Chemistry Wuppertal, Bayer HealthCare AG, 42096 Wuppertal (Germany).
  • Tersteegen A; Lead Discovery Wuppertal, Bayer HealthCare AG, 42096 Wuppertal (Germany).
ChemMedChem ; 10(7): 1163-73, 2015 Jul.
Article em En | MEDLINE | ID: mdl-26083237
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pirimidinonas / Sulfonas / Elastase de Leucócito / Proteínas Secretadas Inibidoras de Proteinases / Congelamento / Pneumopatias Tipo de estudo: Diagnostic_studies Limite: Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pirimidinonas / Sulfonas / Elastase de Leucócito / Proteínas Secretadas Inibidoras de Proteinases / Congelamento / Pneumopatias Tipo de estudo: Diagnostic_studies Limite: Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article