Immunoglobulin with High-Titer In Vitro Cross-Neutralizing Hepatitis C Virus Antibodies Passively Protects Chimpanzees from Homologous, but Not Heterologous, Challenge.
J Virol
; 89(17): 9128-32, 2015 Sep.
Article
em En
| MEDLINE
| ID: mdl-26085160
ABSTRACT
The importance of neutralizing antibodies (NAbs) in protection against hepatitis C virus (HCV) remains controversial. We infused a chimpanzee with H06 immunoglobulin from a genotype 1a HCV-infected patient and challenged with genotype strains efficiently neutralized by H06 in vitro. Genotype 1a NAbs afforded no protection against genotype 4a or 5a. Protection against homologous 1a lasted 18 weeks, but infection emerged when NAb titers waned. However, 6a infection was prevented. The differential in vivo neutralization patterns have implications for HCV vaccine development.
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Imunoglobulinas
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Vacinas contra Hepatite Viral
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Hepacivirus
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Anticorpos Anti-Hepatite C
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Anticorpos Neutralizantes
Limite:
Animals
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Humans
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article