Acute human herpesvirus-6A infection of human mesothelial cells modulates HLA molecules.
Arch Virol
; 160(9): 2141-9, 2015 Sep.
Article
em En
| MEDLINE
| ID: mdl-26085284
ABSTRACT
Human herpesvirus 6A (HHV-6A) causes ubiquitous infections and has been associated with several diseases in immunosuppressed and immune dysregulated individuals. Although considered a lymphotropic virus, HHV-6A has the potential to infect many cell types, inducing important alterations in the infected cell. In our search for additional potential targets for HHV-6A infection, we analyzed the susceptibility of human mesothelial cells to viral infection. HHV-6A infection was performed and analyzed on primary human mesothelial cells isolated from serous cavity fluid, infected in vitro with a cell-free HHV-6A inoculum. The results demonstrated that mesothelial cells are susceptible to in vitro HHV-6A infection, and more importantly, that the virus induces an alteration of HLA expression on the cell surface, inducing HLA class II and HLA-G de novo expression. Since mesothelial cells play a pivotal role in many processes, including inflammation and antigen presentation, we speculate that, in vivo, this virus-induced perturbation might be correlated to alterations in mesothelium functions.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Herpesvirus Humano 6
/
Células Endoteliais
/
Antígenos HLA
Limite:
Humans
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article