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Polyphenol administration impairs T-cell proliferation by imprinting a distinct dendritic cell maturational profile.
Delvecchio, Francesca Romana; Vadrucci, Elisa; Cavalcanti, Elisabetta; De Santis, Stefania; Kunde, Dale; Vacca, Michele; Myers, Jay; Allen, Frederick; Bianco, Giusy; Huang, Alex Y; Monsurro, Vladia; Santino, Angelo; Chieppa, Marcello.
Afiliação
  • Delvecchio FR; IRCCS "de Bellis", Laboratory of Experimental Immunopathology, Castellana Grotte, BA, Italy.
  • Vadrucci E; IRCCS "de Bellis", Laboratory of Experimental Immunopathology, Castellana Grotte, BA, Italy.
  • Cavalcanti E; IRCCS "de Bellis", Laboratory of Experimental Immunopathology, Castellana Grotte, BA, Italy.
  • De Santis S; IRCCS "de Bellis", Laboratory of Experimental Immunopathology, Castellana Grotte, BA, Italy.
  • Kunde D; School of Health Science, University of Tasmania, Launceston, Tasmania, Australia.
  • Vacca M; Mario Negri Sud, Laboratory of Lipid Metabolism and Cancer, Santa Maria Imbaro, CH, Italy.
  • Myers J; Department of Pediatrics, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
  • Allen F; Department of Pediatrics, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
  • Bianco G; IRCCS "de Bellis", Laboratory of Experimental Immunopathology, Castellana Grotte, BA, Italy.
  • Huang AY; Department of Pediatrics, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
  • Monsurro V; Department of Pathology and Diagnostic, University of Verona Medical School, Verona, Italy.
  • Santino A; CNR, Institute of Science of Food Production, Lecce, Italy.
  • Chieppa M; IRCCS "de Bellis", Laboratory of Experimental Immunopathology, Castellana Grotte, BA, Italy.
Eur J Immunol ; 45(9): 2638-49, 2015 Sep.
Article em En | MEDLINE | ID: mdl-26096294
Currently little is known as to how nutritionally derived compounds may affect dendritic cell (DC) maturation and potentially prevent inappropriate inflammatory responses that are characteristic of chronic inflammatory syndromes. Previous observations have demonstrated that two polyphenols quercetin and piperine delivered through reconstituted oil bodies (ROBs-QP) can influence DC maturation in response to LPS leading to a modulated inflammatory response. In the present study, we examined the molecular effects of ROBs-QP exposure on DC differentiation in mice and identified a unique molecular signature in response to LPS administration that potentially modulates DC maturation and activity in inflammatory conditions. Following LPS administration, ROBs-QP-exposed DCs expressed an altered molecular profile as compared with control DCs, including cytokine and chemokine production, chemokine receptor repertoire, and antigen presentation ability. In vivo ROBs-QP administration suppresses antigen-specific T-cell division in the draining lymph nodes resulting from a reduced ability to create stable immunological synapse. Our data demonstrate that polyphenols exposure can drive DCs toward a new anti-inflammatory molecular profile capable of dampening the inflammatory response, highlighting their potential as complementary nutritional approaches in the treatment of chronic inflammatory syndromes.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Piperidinas / Quercetina / Células Dendríticas / Linfócitos T / Proliferação de Células / Alcaloides / Benzodioxóis / Alcamidas Poli-Insaturadas / Polifenóis Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2015 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Piperidinas / Quercetina / Células Dendríticas / Linfócitos T / Proliferação de Células / Alcaloides / Benzodioxóis / Alcamidas Poli-Insaturadas / Polifenóis Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2015 Tipo de documento: Article