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Paternal allelic mutation at the Kcnq1 locus reduces pancreatic ß-cell mass by epigenetic modification of Cdkn1c.
Asahara, Shun-ichiro; Etoh, Hiroaki; Inoue, Hiroyuki; Teruyama, Kyoko; Shibutani, Yuki; Ihara, Yuka; Kawada, Yukina; Bartolome, Alberto; Hashimoto, Naoko; Matsuda, Tomokazu; Koyanagi-Kimura, Maki; Kanno, Ayumi; Hirota, Yushi; Hosooka, Tetsuya; Nagashima, Kazuaki; Nishimura, Wataru; Inoue, Hiroshi; Matsumoto, Michihiro; Higgins, Michael J; Yasuda, Kazuki; Inagaki, Nobuya; Seino, Susumu; Kasuga, Masato; Kido, Yoshiaki.
Afiliação
  • Asahara S; Division of Diabetes and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Hyogo 650-0017, Japan;
  • Etoh H; Division of Medical Chemistry, Department of Biophysics, Kobe University Graduate School of Health Sciences, Hyogo 654-0142, Japan;
  • Inoue H; Division of Medical Chemistry, Department of Biophysics, Kobe University Graduate School of Health Sciences, Hyogo 654-0142, Japan;
  • Teruyama K; Division of Medical Chemistry, Department of Biophysics, Kobe University Graduate School of Health Sciences, Hyogo 654-0142, Japan;
  • Shibutani Y; Division of Diabetes and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Hyogo 650-0017, Japan;
  • Ihara Y; Division of Medical Chemistry, Department of Biophysics, Kobe University Graduate School of Health Sciences, Hyogo 654-0142, Japan;
  • Kawada Y; Division of Medical Chemistry, Department of Biophysics, Kobe University Graduate School of Health Sciences, Hyogo 654-0142, Japan;
  • Bartolome A; Division of Medical Chemistry, Department of Biophysics, Kobe University Graduate School of Health Sciences, Hyogo 654-0142, Japan;
  • Hashimoto N; Division of Diabetes and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Hyogo 650-0017, Japan;
  • Matsuda T; Division of Diabetes and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Hyogo 650-0017, Japan;
  • Koyanagi-Kimura M; Division of Diabetes and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Hyogo 650-0017, Japan;
  • Kanno A; Division of Diabetes and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Hyogo 650-0017, Japan;
  • Hirota Y; Division of Diabetes and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Hyogo 650-0017, Japan;
  • Hosooka T; Division of Diabetes and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Hyogo 650-0017, Japan;
  • Nagashima K; Department of Diabetes and Clinical Nutrition, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan;
  • Nishimura W; Department of Anatomy, Jichi Medical University, Tochigi 329-0498, Japan;
  • Inoue H; Frontier Science Organization, Kanazawa University, Ishikawa 320-8641, Japan;
  • Matsumoto M; Department of Molecular Metabolic Regulation, Diabetes Research Center, Research Institute, National Center for Global Health and Medicine, Tokyo 162-8655, Japan;
  • Higgins MJ; Department of Molecular and Cellular Biology, Roswell Park Cancer Institute, Buffalo, NY 14263;
  • Yasuda K; Department of Metabolic Disorder, Diabetes Research Center, Research Institute, National Center for Global Health and Medicine, Tokyo 162-8655, Japan;
  • Inagaki N; Department of Diabetes and Clinical Nutrition, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan;
  • Seino S; Division of Diabetes and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Hyogo 650-0017, Japan; Division of Molecular and Metabolic Medicine, Department of Physiology and Cell Biology, Kobe University Graduate School of Medicine, Hyogo 650-0017, Japan;
  • Kasuga M; National Center for Global Health and Medicine, Tokyo 162-8655, Japan.
  • Kido Y; Division of Diabetes and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Hyogo 650-0017, Japan; Division of Medical Chemistry, Department of Biophysics, Kobe University Graduate School of Health Sciences, Hyogo 654-0142, Japan; kido@med.kobe-u.ac.jp.
Proc Natl Acad Sci U S A ; 112(27): 8332-7, 2015 Jul 07.
Article em En | MEDLINE | ID: mdl-26100882
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Epigênese Genética / Células Secretoras de Insulina / Canal de Potássio KCNQ1 / Inibidor de Quinase Dependente de Ciclina p57 / Mutação Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2015 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Epigênese Genética / Células Secretoras de Insulina / Canal de Potássio KCNQ1 / Inibidor de Quinase Dependente de Ciclina p57 / Mutação Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2015 Tipo de documento: Article