Direct photocatalytic fluorination of benzylic C-H bonds with N-fluorobenzenesulfonimide.
Chem Commun (Camb)
; 51(59): 11783-6, 2015 Jul 28.
Article
em En
| MEDLINE
| ID: mdl-26107990
ABSTRACT
The late-stage fluorination of common synthetic building blocks and drug leads is an appealing reaction for medicinal chemistry. In particular, fluorination of benzylic C-H bonds provides a means to attenuate drug metabolism at this metabolically labile position. Here we report two complimentary strategies for the direct fluorination of benzylic C-H bonds using N-fluorobenzenesulfonimide and either a decatungstate photocatalyst or AIBN-initiation.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Sulfonamidas
/
Compostos de Benzil
/
Hidrocarbonetos Fluorados
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article