Quantification of Change in Pigment Epithelial Detachment Volume and Morphology After Transition to Intravitreal Aflibercept in Eyes With Recalcitrant Neovascular AMD: 18-Month Results.
Ophthalmic Surg Lasers Imaging Retina
; 46(6): 638-41, 2015 Jun.
Article
em En
| MEDLINE
| ID: mdl-26114844
ABSTRACT
BACKGROUND AND OBJECTIVE:
To quantitatively evaluate the change in pigment epithelial detachment (PED) morphology on spectral-domain optical coherence tomography (SD-OCT) 18 months after the transition to intravitreal aflibercept in patients with neovascular age-related macular degeneration (AMD) with PED recalcitrant to monthly intravitreal bevacizumab or ranibizumab. PATIENTS ANDMETHODS:
Retrospective case series examining patients with neovascular AMD who had a persistent fibrovascular or serous PED on SD-OCT. PED volume was calculated by manually outlining the PED on individual OCT slices of the raster scan and multiplying by the pixel dimensions.RESULTS:
Eleven eyes of 10 patients who had received an average of 25.7 ± 20.1 (range 6 to 70) prior bevacizumab or ranibizumab injections over a period of 26.6 ± 19.8 months (range 4 to 63) were included. PED volume decreased with aflibercept from 0.687 ± 0.837 mm(3) to 0.562 ± 0.705 mm(3) (P = .02), a decrease of 19% ± 12.27%.CONCLUSION:
After 18 months of aflibercept, recalcitrant PED volumes were reduced by 19% while preserving visual acuity in eyes with neovascular AMD.
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Proteínas Recombinantes de Fusão
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Descolamento Retiniano
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Neovascularização Retiniana
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Inibidores da Angiogênese
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Receptores de Fatores de Crescimento do Endotélio Vascular
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Epitélio Pigmentado da Retina
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Degeneração Macular
Limite:
Aged
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Aged80
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Female
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Humans
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Male
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article