Catalytic Properties of Intramembrane Aspartyl Protease Substrate Hydrolysis Evaluated Using a FRET Peptide Cleavage Assay.

Naing, Swe-Htet; Vukoti, Krishna M; Drury, Jason E; Johnson, Jennifer L; Kalyoncu, Sibel; Hill, Shannon E; Torres, Matthew P; Lieberman, Raquel L

Naing, Swe-Htet; Vukoti, Krishna M; Drury, Jason E; Johnson, Jennifer L; Kalyoncu, Sibel; Hill, Shannon E; Torres, Matthew P; Lieberman, Raquel L.

Afiliação

Naing SH; School of Chemistry and Biochemistry, Georgia Institute of Technology , 901 Atlantic Drive Northwest, Atlanta, Georgia 30332-0400, United States.
Vukoti KM; School of Biology, Georgia Institute of Technology , 310 Ferst Drive Northwest, Atlanta, Georgia 30332-0230, United States.
Drury JE; School of Chemistry and Biochemistry, Georgia Institute of Technology , 901 Atlantic Drive Northwest, Atlanta, Georgia 30332-0400, United States.
Johnson JL; School of Chemistry and Biochemistry, Georgia Institute of Technology , 901 Atlantic Drive Northwest, Atlanta, Georgia 30332-0400, United States.
Kalyoncu S; School of Chemistry and Biochemistry, Georgia Institute of Technology , 901 Atlantic Drive Northwest, Atlanta, Georgia 30332-0400, United States.
Hill SE; School of Chemistry and Biochemistry, Georgia Institute of Technology , 901 Atlantic Drive Northwest, Atlanta, Georgia 30332-0400, United States.
Torres MP; School of Biology, Georgia Institute of Technology , 310 Ferst Drive Northwest, Atlanta, Georgia 30332-0230, United States.
Lieberman RL; School of Chemistry and Biochemistry, Georgia Institute of Technology , 901 Atlantic Drive Northwest, Atlanta, Georgia 30332-0400, United States.

ACS Chem Biol ; 10(9): 2166-74, 2015 Sep 18.

Article em En | MEDLINE | ID: mdl-26118406

Assuntos

Ácido Aspártico Proteases/metabolismo; Methanomicrobiaceae/enzimologia; Peptídeos/metabolismo; Angiotensinogênio/química; Angiotensinogênio/metabolismo; Ácido Aspártico Proteases/antagonistas & inibidores; Ácido Aspártico Proteases/química; Ácido Aspártico Proteases/genética; Inibidores Enzimáticos/farmacologia; Transferência Ressonante de Energia de Fluorescência; Hidrólise/efeitos dos fármacos; Methanomicrobiaceae/química; Methanomicrobiaceae/genética; Methanomicrobiaceae/metabolismo; Modelos Moleculares; Peptídeos/química; Deleção de Sequência; Especificidade por Substrato

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Peptídeos / Methanomicrobiaceae / Ácido Aspártico Proteases Tipo de estudo: Risk_factors_studies Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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