The Mouse Genomes Project: a repository of inbred laboratory mouse strain genomes.
Mamm Genome
; 26(9-10): 403-12, 2015 Oct.
Article
em En
| MEDLINE
| ID: mdl-26123534
ABSTRACT
The Mouse Genomes Project was initiated in 2009 with the goal of using next-generation sequencing technologies to catalogue molecular variation in the common laboratory mouse strains, and a selected set of wild-derived inbred strains. The initial sequencing and survey of sequence variation in 17 inbred strains was completed in 2011 and included comprehensive catalogue of single nucleotide polymorphisms, short insertion/deletions, larger structural variants including their fine scale architecture and landscape of transposable element variation, and genomic sites subject to post-transcriptional alteration of RNA. From this beginning, the resource has expanded significantly to include 36 fully sequenced inbred laboratory mouse strains, a refined and updated data processing pipeline, and new variation querying and data visualisation tools which are available on the project's website ( http//www.sanger.ac.uk/resources/mouse/genomes/ ). The focus of the project is now the completion of de novo assembled chromosome sequences and strain-specific gene structures for the core strains. We discuss how the assembled chromosomes will power comparative analysis, data access tools and future directions of mouse genetics.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Processamento Pós-Transcricional do RNA
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Genoma
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Polimorfismo de Nucleotídeo Único
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Camundongos Endogâmicos
Limite:
Animals
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article