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Pterygium in patients from Goiânia, Goiás, Brazil.
Dos Reis, G M; de P R Júnior, A; E Silva, K S F; Rodrigues, D A; Gomes, M C S; Martins, J V M; da Costa, I R; Freitas, G A; Moura, K K O.
Afiliação
  • Dos Reis GM; Replicon, Pontifícia Universidade Católica de Goiás, Goiânia, GO, Brasil.
  • de P R Júnior A; Replicon, Pontifícia Universidade Católica de Goiás, Goiânia, GO, Brasil.
  • E Silva KS; Laboratório de Genética e Biologia Molecular, Universidade Federal de Goiás, Goiânia, GO, Brasil smallbinho@hotmail.com.
  • Rodrigues DA; Replicon, Pontifícia Universidade Católica de Goiás, Goiânia, GO, Brasil.
  • Gomes MC; Replicon, Pontifícia Universidade Católica de Goiás, Goiânia, GO, Brasil.
  • Martins JV; Replicon, Pontifícia Universidade Católica de Goiás, Goiânia, GO, Brasil.
  • da Costa IR; Replicon, Pontifícia Universidade Católica de Goiás, Goiânia, GO, Brasil.
  • Freitas GA; Replicon, Pontifícia Universidade Católica de Goiás, Goiânia, GO, Brasil.
  • Moura KK; Laboratório de Genética e Biologia Molecular, Universidade Federal de Goiás, Goiânia, GO, Brasil.
Genet Mol Res ; 14(2): 6182-8, 2015 Jun 11.
Article em En | MEDLINE | ID: mdl-26125819
ABSTRACT
Pterygium is an inflammatory and degenerative ocular surface disease in which the conjunctiva on the cornea grows to form a fibrous tissue in the shape of a triangle. The disorder may be characterized by cell proliferation, inflammatory processes, fibrosis, angiogenesis, and destruction of the extracellular matrix. The anomaly is considered a degenerative eye disease and is erroneously confused with cataract. It displays similar features to those of tumors, such as local invasion, metaplasia of epithelial cells, presence of oncogenic viruses (human papilloma virus), inactivation of tumor suppressor genes (e.g., p53), and loss of heterozygosity. The treatment of pterygium is based on factors such as the evolution and progression of the disease, risk factors, symptoms, and patient age. Considerations about the best technique for the surgical removal of pterygium remain controversial, and complications and recurrence are very common. The development of new surgical techniques and adjuvant drugs is thus necessary. This study aims to analyze and compare the frequency of the GSTT1 genotypes in relation to pterygium through statistical analyzes in order to build a genotypic profile for the Replicon patients. The genotypic profile of the GSTT1-null polymorphism in Goiânia showed no significant difference when the frequency of the null genotype was compared between the control and experimental groups. The null genotype was more frequent in the population studied. Furthermore, the GSTT1 genotype was not related to the analyzed risk factors for pterygium, namely gender, ethnicity, family history, occupational exposure, smoking, hypertension, and diabetes.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Polimorfismo Genético / Pterígio / Glutationa Transferase Tipo de estudo: Diagnostic_studies / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Female / Humans / Male País como assunto: America do sul / Brasil Idioma: En Ano de publicação: 2015 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Polimorfismo Genético / Pterígio / Glutationa Transferase Tipo de estudo: Diagnostic_studies / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Female / Humans / Male País como assunto: America do sul / Brasil Idioma: En Ano de publicação: 2015 Tipo de documento: Article