Etomidate Impairs Long-Term Potentiation In Vitro by Targeting &#945;5-Subunit Containing GABAA Receptors on Nonpyramidal Cells.

Rodgers, F Clifford; Zarnowska, Ewa D; Laha, Kurt T; Engin, Elif; Zeller, Anja; Keist, Ruth; Rudolph, Uwe; Pearce, Robert A

Etomidate Impairs Long-Term Potentiation In Vitro by Targeting α5-Subunit Containing GABAA Receptors on Nonpyramidal Cells.

Rodgers, F Clifford; Zarnowska, Ewa D; Laha, Kurt T; Engin, Elif; Zeller, Anja; Keist, Ruth; Rudolph, Uwe; Pearce, Robert A.

Afiliação

Rodgers FC; Neuroscience Training Program and Department of Anesthesiology, University of Wisconsin-Madison, Madison, Wisconsin 53706.
Zarnowska ED; Department of Anesthesiology, University of Wisconsin-Madison, Madison, Wisconsin 53706.
Laha KT; Department of Anesthesiology, University of Wisconsin-Madison, Madison, Wisconsin 53706.
Engin E; Laboratory of Genetic Neuropharmacology, McLean Hospital, Belmont, Massachusetts 02478, Department of Psychiatry, Harvard Medical School, Boston, Massachusetts 02215, and.
Zeller A; Institute of Pharmacology and Toxicology, University of Zurich, CH-8057 Zurich, Switzerland.
Keist R; Institute of Pharmacology and Toxicology, University of Zurich, CH-8057 Zurich, Switzerland.
Rudolph U; Laboratory of Genetic Neuropharmacology, McLean Hospital, Belmont, Massachusetts 02478, Department of Psychiatry, Harvard Medical School, Boston, Massachusetts 02215, and.
Pearce RA; Department of Anesthesiology, University of Wisconsin-Madison, Madison, Wisconsin 53706, rapearce@wisc.edu.

J Neurosci ; 35(26): 9707-16, 2015 Jul 01.

Article em En | MEDLINE | ID: mdl-26134653

Assuntos

Etomidato/farmacologia; Hipocampo/citologia; Hipnóticos e Sedativos/farmacologia; Potenciação de Longa Duração/efeitos dos fármacos; Neurônios/efeitos dos fármacos; Receptores de GABA-A/metabolismo; Animais; Biofísica; Estimulação Elétrica; Antagonistas de Aminoácidos Excitatórios/farmacologia; Antagonistas GABAérgicos/farmacologia; Técnicas In Vitro; Ácido Cinurênico; Potenciação de Longa Duração/genética; Camundongos; Camundongos Endogâmicos C57BL; Camundongos Knockout; Neurônios/fisiologia; Picrotoxina/farmacologia; Receptores de GABA-A/genética; Ácido gama-Aminobutírico/farmacologia

Palavras-chave

GABAA receptor; LTP; learning and memory; mechanisms of anesthesia

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Potenciação de Longa Duração / Receptores de GABA-A / Etomidato / Hipocampo / Hipnóticos e Sedativos / Neurônios Limite: Animals Idioma: En Ano de publicação: 2015 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google