Asymmetric Total Synthesis of (-)-Maoecrystalâ
V.
Chem Asian J
; 10(9): 1874-80, 2015 Sep.
Article
em En
| MEDLINE
| ID: mdl-26136342
ABSTRACT
The asymmetric total synthesis of (-)-maoecrystalâ
V, a novel cytotoxic pentacyclic ent-kaurane diterpene, has been accomplished. Key steps of the current strategy involve an early-stage semipinacol rearrangement reaction for the construction of the C10 quaternary stereocenter, a rhodium-catalyzed intramolecular O-H insertion reaction, and a sequential Wessely oxidative dearomatization/intramolecular Diels-Alder reaction to forge the pentacyclic framework of maoecrystalâ
V.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Citotoxinas
/
Diterpenos
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article