A Basis for Rapid Clearance of Circulating Ring-Stage Malaria Parasites by the Spiroindolone KAE609.
J Infect Dis
; 213(1): 100-4, 2016 Jan 01.
Article
em En
| MEDLINE
| ID: mdl-26136472
ABSTRACT
Recent clinical trials revealed a surprisingly rapid clearance of red blood cells (RBCs) infected with malaria parasites by the spiroindolone KAE609. Here, we show that ring-stage parasite-infected RBCs exposed to KAE609 become spherical and rigid, probably through osmotic dysregulation consequent to the disruption of the parasite's sodium efflux pump (adenosine triphosphate 4). We also show that this peculiar drug effect is likely to cause accelerated splenic clearance of the rheologically impaired Plasmodium vivax- and Plasmodium falciparum-infected RBCs.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Plasmodium falciparum
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Plasmodium vivax
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Compostos de Espiro
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Malária Falciparum
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Indóis
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Antimaláricos
Limite:
Humans
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article