Astrocytic IL-6 mediates locomotor activity, exploration, anxiety, learning and social behavior.
Horm Behav
; 73: 64-74, 2015 Jul.
Article
em En
| MEDLINE
| ID: mdl-26143620
ABSTRACT
Interleukin-6 (IL-6) is a major cytokine in the central nervous system, secreted by different brain cells and with roles in a number of physiological functions. We herewith confirm and expand the importance of astrocytic production of and response to IL-6 by using transgenic mice deficient in astrocytic IL-6 (Ast-IL-6 KO) or in its receptor (Ast-IL-6R KO) in full C57Bl/6 genetic background. A major prosurvival effect of astrocytic IL-6 at early ages was clearly demonstrated. Robust effects were also evident in the control of activity and anxiety in the hole-board and elevated plus-maze, and in spatial learning in the Morris water-maze. The results also suggest an inhibitory role of IL-6 in the mechanism controlling the consolidation of hippocampus-dependent spatial learning. Less robust effects of astrocytic IL-6 system were also observed in despair behavior in the tail suspension test, and social behavior in the dominance and resident-intruder tests. The behavioral phenotype was highly dependent on age and/or sex in some cases. The phenotype of Ast-IL-6R KO mice mimicked only partially that of Ast-IL-6KO mice, which indicates both a role of astrocytes in behavior and the participation of other cells besides astrocytes. No evidences of altered function of the hypothalamic-pituitary-adrenal axis were observed. These results demonstrate that astrocytic IL-6 (acting at least partially in astrocytes) regulates normal behavior in mice.
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Base de dados:
MEDLINE
Assunto principal:
Ansiedade
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Comportamento Social
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Astrócitos
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Interleucina-6
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Comportamento Exploratório
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Aprendizagem
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Atividade Motora
Limite:
Animals
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article