Metal-Free Decarboxylative Cyclization/Ring Expansion: Construction of Five-, Six-, and Seven-Membered Heterocycles from 2-Alkynyl Benzaldehydes and Cyclic Amino Acids.
Angew Chem Int Ed Engl
; 54(33): 9564-7, 2015 Aug 10.
Article
em En
| MEDLINE
| ID: mdl-26148838
ABSTRACT
A one pot synthesis of 1H-benzo[g]indoles, tetrahydrobenzo[h]quinolines, and naphtho[1,2-b]azepines from 2-alkynyl benzaldehydes and cyclic amino acids is reported. The salient feature of the strategy involves formation of three new bonds (one C-N and two C-C bonds) by a metal-free decarboxylation/cyclization/one-carbon ring expansion sequence in one pot.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Quinolinas
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Azepinas
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Benzaldeídos
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Derivados de Benzeno
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Aminoácidos Cíclicos
/
Indóis
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article