A Variegated Squirrel Bornavirus Associated with Fatal Human Encephalitis.
N Engl J Med
; 373(2): 154-62, 2015 Jul 09.
Article
em En
| MEDLINE
| ID: mdl-26154788
ABSTRACT
Between 2011 and 2013, three breeders of variegated squirrels (Sciurus variegatoides) had encephalitis with similar clinical signs and died 2 to 4 months after onset of the clinical symptoms. With the use of a metagenomic approach that incorporated next-generation sequencing and real-time reverse-transcriptase quantitative polymerase chain reaction (RT-qPCR), the presence of a previously unknown bornavirus was detected in a contact squirrel and in brain samples from the three patients. Phylogenetic analyses showed that this virus, tentatively named variegated squirrel 1 bornavirus (VSBV-1), forms a lineage separate from that of the known bornavirus species. (Funded by the Federal Ministry of Food and Agriculture [Germany] and others.).
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Sciuridae
/
Encéfalo
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Infecções por Mononegavirales
/
Encefalite Viral
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Bornaviridae
Tipo de estudo:
Risk_factors_studies
Limite:
Aged
/
Animals
/
Humans
/
Male
/
Middle aged
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article