Nanoparticles for Radiation Therapy Enhancement: the Key Parameters.
Theranostics
; 5(9): 1030-44, 2015.
Article
em En
| MEDLINE
| ID: mdl-26155318
ABSTRACT
This review focuses on the radiosensitization strategies that use high-Z nanoparticles. It does not establish an exhaustive list of the works in this field but rather propose constructive criticisms pointing out critical factors that could improve the nano-radiation therapy. Whereas most reviews show the chemists and/or biologists points of view, the present analysis is also seen through the prism of the medical physicist. In particular, we described and evaluated the influence of X-rays energy spectra using a numerical analysis. We observed a lack of standardization in preclinical studies that could partially explain the low number of translation to clinical applications for this innovative therapeutic strategy. Pointing out the critical parameters of high-Z nanoparticles radiosensitization, this review is expected to contribute to a larger preclinical and clinical development.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Radiossensibilizantes
/
Radioterapia
/
Nanopartículas
Limite:
Animals
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article