Acid heteropolysaccharides with potent antileishmanial effects.
Int J Biol Macromol
; 81: 165-70, 2015 Nov.
Article
em En
| MEDLINE
| ID: mdl-26162246
ABSTRACT
The present study investigated in vitro the effects of sulphated heterorhamnan (Go3), iota-/nu-carrageenans (G3d and EHW-I) and arabinogalactan (ARAGAL) polysaccharides on macrophage activation and inhibition of intracellular amastigotes of Leishmania (L.) amazonensis. All the sulphated polysaccharides (Go3, G3d and EHW-I) promoted increased nitric oxide production varying from 71 to 110%. The leishmanicidal activity of all compounds was compared to the inhibition effect of Meglumine Antimoniate at 300µg/mL (â¼79%), used as positive control. Inhibition of Leishmania (L.) amazonensis growth was 55% with 5µg/mL of Go3, 50% and 98% to G3d and EHW-I, respectively at 10µg/mL, and 88% with 10µg/mL of ARAGAL. The superoxide anion scavenging activity for the sulphated polysaccharides varied from approximately 30-55% at 10µg/mL. In conclusion, the results of the present study indicate the promising potential of these polysaccharides for the development of new alternative therapeutic agents against leishmaniasis.
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Base de dados:
MEDLINE
Assunto principal:
Polissacarídeos
/
Tripanossomicidas
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Leishmania
Limite:
Animals
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article