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Novel riboswitch-binding flavin analog that protects mice against Clostridium difficile infection without inhibiting cecal flora.
Blount, Kenneth F; Megyola, Cynthia; Plummer, Mark; Osterman, David; O'Connell, Tim; Aristoff, Paul; Quinn, Cheryl; Chrusciel, R Alan; Poel, Toni J; Schostarez, Heinrich J; Stewart, Catherine A; Walker, Daniel P; Wuts, Peter G M; Breaker, Ronald R.
Afiliação
  • Blount KF; Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, Connecticut, USA BioRelix Inc., Foxborough, Massachusetts, USA ken.blount@yale.edu ronald.breaker@yale.edu.
  • Megyola C; Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, Connecticut, USA.
  • Plummer M; Yale Center for Molecular Discovery, Yale University, New Haven, Connecticut, USA.
  • Osterman D; BioRelix Inc., Foxborough, Massachusetts, USA.
  • O'Connell T; BioRelix Inc., Foxborough, Massachusetts, USA.
  • Aristoff P; Aristoff Consulting LLC, Fort Collins, Colorado, USA.
  • Quinn C; QnA Pharma Consulting, LLC, Minneapolis, Minnesota, USA.
  • Chrusciel RA; Kalexsyn, Inc., Kalamazoo, Michigan, USA.
  • Poel TJ; Kalexsyn, Inc., Kalamazoo, Michigan, USA.
  • Schostarez HJ; Kalexsyn, Inc., Kalamazoo, Michigan, USA.
  • Stewart CA; Kalexsyn, Inc., Kalamazoo, Michigan, USA.
  • Walker DP; Kalexsyn, Inc., Kalamazoo, Michigan, USA.
  • Wuts PG; Kalexsyn, Inc., Kalamazoo, Michigan, USA.
  • Breaker RR; Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, Connecticut, USA Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut, USA Howard Hughes Medical Institute, Yale University, New Haven, Connecticut, USA ken.blount@yale.ed
Antimicrob Agents Chemother ; 59(9): 5736-46, 2015 Sep.
Article em En | MEDLINE | ID: mdl-26169403
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Enterocolite Pseudomembranosa / Ceco / Clostridioides difficile / Flavinas / Mononucleotídeo de Flavina / Antibacterianos Limite: Animals Idioma: En Ano de publicação: 2015 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Enterocolite Pseudomembranosa / Ceco / Clostridioides difficile / Flavinas / Mononucleotídeo de Flavina / Antibacterianos Limite: Animals Idioma: En Ano de publicação: 2015 Tipo de documento: Article