A rescue act: Translesion DNA synthesis past N(2) -deoxyguanosine adducts.
IUBMB Life
; 67(7): 564-74, 2015 Jul.
Article
em En
| MEDLINE
| ID: mdl-26173005
ABSTRACT
Genomic DNA is continually subjected to a number of chemical insults that result in the formation of modified nucleotides--termed as DNA lesions. The N(2) -atom of deoxyguanosine is particularly reactive and a number of chemicals react at this site to form different kinds of DNA adducts. The N(2) -deoxyguanosine adducts perturb different genomic processes and are particularly deleterious for DNA replication as they have a strong tendency to inhibit replicative DNA polymerases. Many organisms possess specialized dPols--generally classified in the Y-family--that serves to rescue replication stalled at N(2) -dG and other adducts. A review of minor groove N(2) -adducts and the known strategies utilized by Y-family dPols to replicate past these lesions will be presented here.
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Base de dados:
MEDLINE
Assunto principal:
DNA
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Adutos de DNA
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Desoxiguanosina
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DNA Polimerase Dirigida por DNA
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Replicação do DNA
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article