Rash and multiorgan dysfunction following lamotrigine: could genetic be involved?
Int J Clin Pharm
; 37(5): 682-6, 2015 Oct.
Article
em En
| MEDLINE
| ID: mdl-26173940
ABSTRACT
CASE (DESCRIPTION) We report the case of a 38-year-old woman treated with lamotrigine who experienced multi-organ dysfunction. The patient received the drug at the dose of 100 mg per day. One week later, the treatment was suspended because of an extensive body rash. Twenty-four hours later, the patient appeared drowsy and stuporous and was hospitalized. On the fifth day, the patient was admitted with a clinical picture of acute multi-organ failure in our Institute, where, she, despite the support of vital functions with vasoactive drugs, continuous hemofiltration and ventilation with oxygen, died. Serum lamotrigine concentration was measured 110 h after its last dose and the drug resulted to be still present at 1 mg/L. The patient was homozygous for the UGT1A4-70C and UGT2B7-161C alleles and heterozygous for the UGT2B7-372A>G polymorphism. Regarding ABCB1 the patient showed the 3435CC, 2677GT and 1236CT genotypes. CONCLUSION:
Our results may suggest a role of the UGT2B7-372A>G polymorphism in this reaction.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Triazinas
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Glucuronosiltransferase
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Exantema
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Insuficiência de Múltiplos Órgãos
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Anticonvulsivantes
Limite:
Female
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Humans
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article