The cerebrospinal fluid biomarker profile in an HIV-infected subject with Alzheimer's disease.
AIDS Res Ther
; 12: 23, 2015.
Article
em En
| MEDLINE
| ID: mdl-26175795
ABSTRACT
It is a challenge to differentiate between HIV-associated neurocognitive disorders (HAND) and other types of neurocognitive disease in the ageing HIV-infected population. Here we describe a 63 year old HIV-infected woman who had a history, neuropsychological test result, and PET examination consistent with characteristic Alzheimer's disease (AD). The cerebrospinal fluid (CSF) biomarker profile was analogous to the profile typically found in AD in HIV-negative patients with increased t-tau and p-tau, a decreased level of Aß42 and normal levels of CSF neurofilament light protein and sAPPα and sAPPß, distinctly different from findings in HIV-associated dementia (HAD). Assessment of CSF biomarkers may be a valuable tool for clinicians to distinguish between HAD and AD.
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MEDLINE
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En
Ano de publicação:
2015
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Article