Translating Molecular Recognition into a Pressure Signal to enable Rapid, Sensitive, and Portable Biomedical Analysis.
Angew Chem Int Ed Engl
; 54(36): 10448-53, 2015 Sep 01.
Article
em En
| MEDLINE
| ID: mdl-26180027
ABSTRACT
Herein, we demonstrate that a very familiar, yet underutilized, physical parametergas pressurecan serve as signal readout for highly sensitive bioanalysis. Integration of a catalyzed gas-generation reaction with a molecular recognition component leads to significant pressure changes, which can be measured with high sensitivity using a low-cost and portable pressure meter. This new signaling strategy opens up a new way for simple, portable, yet highly sensitive biomedical analysis in a variety of settings.
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Base de dados:
MEDLINE
Assunto principal:
Pressão
Tipo de estudo:
Diagnostic_studies
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article