Hemoglobinopathy Screening in a 15-Year-old Patient With Anemia.
J Pediatr Hematol Oncol
; 37(6): 472-3, 2015 Aug.
Article
em En
| MEDLINE
| ID: mdl-26181419
ABSTRACT
Identification of hemoglobinopathies in pediatric patients can be challenging and has important implications for the patient, as well as family members. Laboratory identification of uncommon hemoglobin (Hb) variants can pose a significant problem. Although many Hb variants can be largely identified using conventional electrophoresis and HPLC, confirmatory Hb DNA analysis may be necessary. This report provides an example of a pediatric patient with a complex heterozygous Hb by electrophoresis and HPLC, which necessitated identification by DNA analysis. Clinical and laboratory scenarios warranting Hb DNA analysis are additionally discussed.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Hemoglobinas Anormais
/
Hemoglobinopatias
/
Anemia
Tipo de estudo:
Diagnostic_studies
/
Etiology_studies
/
Prognostic_studies
/
Screening_studies
Limite:
Adolescent
/
Female
/
Humans
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article