Total Synthesis of Aquatolide.
Org Lett
; 17(15): 3892-4, 2015 Aug 07.
Article
em En
| MEDLINE
| ID: mdl-26186274
ABSTRACT
A total synthesis of the sesquiterpene lactone aquatolide has been accomplished. The central step is an intramolecular [2 + 2]-photocycloaddition of an allene onto an α,ß-unsaturated δ-lactone. Other key steps are an intramolecular Horner-Wadsworth-Emmons reaction to close the lactone and an intramolecular Mukaiyama-type aldol reaction to cyclize the eight-membered ring. Racemic aquatolide has been resolved using preparative HPLC.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Sesquiterpenos
/
Lactonas
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article