The endocrine dyscrasia that accompanies menopause and andropause induces aberrant cell cycle signaling that triggers re-entry of post-mitotic neurons into the cell cycle, neurodysfunction, neurodegeneration and cognitive disease.

Atwood, Craig S; Bowen, Richard L

Atwood, Craig S; Bowen, Richard L.

Afiliação

Atwood CS; Department of Medicine, University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI 53705, USA; Geriatric Research, Education and Clinical Center, Veterans Administration Hospital, Madison, WI 53705, USA; School of Exercise, Biomedical and Health Sciences, Edith Cowan University, Joondalup, 6027 WA, Australia. Electronic address: csa@medicine.wisc.edu.
Bowen RL; OTB Research, 217 Calhoun St, Unit 1, Charleston, SC 29401, USA.

Horm Behav ; 76: 63-80, 2015 Nov.

Article em En | MEDLINE | ID: mdl-26188949

Assuntos

Andropausa/fisiologia; Ciclo Celular/fisiologia; Transtornos Cognitivos/metabolismo; Menopausa/metabolismo; Doenças Neurodegenerativas/metabolismo; Neurônios/metabolismo; Transdução de Sinais/fisiologia; Animais; Humanos

Palavras-chave

Alzheimer's disease; Amyloid-beta precursor protein; Andropause; Bloodbrain barrier; Cdk-5; Cell cycle re-entry; Cognition; Dyotic signaling; Endocrine dyscrasia; Gonadotropin-releasing hormone; Hormone replacement therapy; Hypothalamicpituitarygonadal axis; Luteinizing hormone; Menopause; Parkinson's disease; Senescence; Sex steroids; Stroke; Tau

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Menopausa / Transdução de Sinais / Ciclo Celular / Transtornos Cognitivos / Doenças Neurodegenerativas / Andropausa / Neurônios Limite: Animals / Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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