Sex hormone-related neurosteroids differentially rescue bioenergetic deficits induced by amyloid-ß or hyperphosphorylated tau protein.

Grimm, Amandine; Biliouris, Emily E; Lang, Undine E; Götz, Jürgen; Mensah-Nyagan, Ayikoe Guy; Eckert, Anne

Grimm, Amandine; Biliouris, Emily E; Lang, Undine E; Götz, Jürgen; Mensah-Nyagan, Ayikoe Guy; Eckert, Anne.

Afiliação

Grimm A; Neurobiology Laboratory for Brain Aging and Mental Health, Transfaculty Research Platform, Molecular and Cognitive Neuroscience, University of Basel, Wilhelm Klein-Str. 27, 4012, Basel, Switzerland.
Biliouris EE; Psychiatric University Clinics, University of Basel, Wilhelm Klein-Str. 27, 4012, Basel, Switzerland.
Lang UE; Biopathologie de la Myéline, Neuroprotection et Stratégies Thérapeutiques, INSERM U1119, Fédération de Médecine Translationnelle de Strasbourg (FMTS), Université de Strasbourg, Bâtiment 3 de la Faculté de Médecine, 11 rue Humann, 67 000, Strasbourg, France.
Götz J; Neurobiology Laboratory for Brain Aging and Mental Health, Transfaculty Research Platform, Molecular and Cognitive Neuroscience, University of Basel, Wilhelm Klein-Str. 27, 4012, Basel, Switzerland.
Mensah-Nyagan AG; Psychiatric University Clinics, University of Basel, Wilhelm Klein-Str. 27, 4012, Basel, Switzerland.
Eckert A; Psychiatric University Clinics, University of Basel, Wilhelm Klein-Str. 27, 4012, Basel, Switzerland.

Cell Mol Life Sci ; 73(1): 201-15, 2016 Jan.

Article em En | MEDLINE | ID: mdl-26198711

Assuntos

Trifosfato de Adenosina/metabolismo; Doença de Alzheimer/metabolismo; Precursor de Proteína beta-Amiloide/metabolismo; Hormônios Esteroides Gonadais/metabolismo; Neurotransmissores/metabolismo; Proteínas tau/metabolismo; Doença de Alzheimer/genética; Doença de Alzheimer/patologia; Precursor de Proteína beta-Amiloide/genética; Linhagem Celular; Metabolismo Energético; Humanos; Potencial da Membrana Mitocondrial; Neurônios/metabolismo; Neurônios/patologia; Fosforilação; Mutação Puntual; Regulação para Cima; Proteínas tau/genética

Palavras-chave

Amyloid-ß peptide; Bioenergetics; Mitochondria; Neurosteroids; Tau protein

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Hormônios Esteroides Gonadais / Trifosfato de Adenosina / Precursor de Proteína beta-Amiloide / Proteínas tau / Neurotransmissores / Doença de Alzheimer Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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