Caught Off Center: Rethinking the Requirements for Antibody Affinity Maturation.
Immunity
; 43(1): 5-6, 2015 Jul 21.
Article
em En
| MEDLINE
| ID: mdl-26200006
ABSTRACT
Antibody affinity maturation involves selective survival of high affinity B cells and is thought to require the germinal center (GC) microenvironment. In this issue of Immunity, Di Niro et al. (2015) challenge this view, showing that low affinity B cells initiate Salmonella responses and affinity mature outside of GCs.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Salmonella typhimurium
/
Linfócitos B
/
Centro Germinativo
/
Hipermutação Somática de Imunoglobulina
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Seleção Clonal Mediada por Antígeno
Limite:
Animals
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article