CD4+ T cells in aged or thymectomized recipients of allogeneic stem cell transplantations.
Biol Res
; 48: 41, 2015 Jul 26.
Article
em En
| MEDLINE
| ID: mdl-26210500
ABSTRACT
BACKGROUND:
CD4+CD25highFOXP3+ regulatory T (Treg) cells, which include thymus-derived and peripherally induced cells, play a central role in immune regulation, and are therefore crucial to prevent graft-versus-host disease (GVHD). The increasing use of allogeneic hematopoietic stem cell transplantation (allo-HSCT) for elderly patients with thymus regression, and our case of allo-HSCT shortly after total thymectomy, raised questions about the activity of thymus-derived Treg cells and peripherally induced Treg cells, which are otherwise indistinguishable.RESULTS:
We found that despite pre-transplant thymectomy or older age, both naïve and effector Treg cells, as well as naïve and effector conventional T cells, proliferated in allo-HSCT recipients. Higher proportions of total Treg cells 1 month post allo-HSCT, and naïve Treg cells 1 year post allo-HSCT, appeared in patients achieving complete chimera without developing significant chronic GVHD, including our thymectomized patient, compared with patients who developed chronic GVHD.CONCLUSIONS:
Treg cells that modulate human allogeneic immunity may arise peripherally as well as in the thymus of allo-HSCT recipients.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Timectomia
/
Linfócitos T CD4-Positivos
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Transplante de Células-Tronco Hematopoéticas
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Doença Enxerto-Hospedeiro
Limite:
Adult
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article