NOP14 suppresses breast cancer progression by inhibiting NRIP1/Wnt/ß-catenin pathway.
Oncotarget
; 6(28): 25701-14, 2015 Sep 22.
Article
em En
| MEDLINE
| ID: mdl-26213846
ABSTRACT
NOP14, which is functionally conserved among eukaryotes, has been implicated in cancer development. Here, we show that NOP14 is poorly expressed in breast cancer cells and invasive breast cancer tissues. In vivo and in vitro studies indicated that NOP14 suppressed the tumorigenesis and metastasis of breast cancer cells. Further investigations revealed that NOP14 enhanced ERα expression and inhibited the Wnt/ß-catenin pathway by up-regulating NRIP1 expression. Survival analysis indicated that low NOP14 expression was significantly associated with poor overall survival (P = 0.0006) and disease-free survival (P = 0.0007), suggesting that NOP14 is a potential prognostic factor in breast cancer. Taken together, our findings reveal that NOP14 may suppress breast cancer progression and provide new insights into the development of targeted therapeutic agents for breast cancer.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Mama
/
Proteínas Nucleares
/
Biomarcadores Tumorais
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Proteínas Adaptadoras de Transdução de Sinal
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Beta Catenina
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Via de Sinalização Wnt
Tipo de estudo:
Prognostic_studies
Limite:
Adult
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Animals
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Female
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Humans
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article