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AAV9 delivering a modified human Mullerian inhibiting substance as a gene therapy in patient-derived xenografts of ovarian cancer.
Pépin, David; Sosulski, Amanda; Zhang, Lihua; Wang, Dan; Vathipadiekal, Vinod; Hendren, Katherine; Coletti, Caroline M; Yu, Aaron; Castro, Cesar M; Birrer, Michael J; Gao, Guangping; Donahoe, Patricia K.
Afiliação
  • Pépin D; Pediatric Surgical Research Laboratories, Massachusetts General Hospital, Department of Surgery, Harvard Medical School, Boston, MA 02114;
  • Sosulski A; Pediatric Surgical Research Laboratories, Massachusetts General Hospital, Department of Surgery, Harvard Medical School, Boston, MA 02114;
  • Zhang L; Pediatric Surgical Research Laboratories, Massachusetts General Hospital, Department of Surgery, Harvard Medical School, Boston, MA 02114;
  • Wang D; Gene Therapy Center, University of Massachusetts Medical School, Worcester, MA 01655;
  • Vathipadiekal V; Gynecological Oncology, Massachusetts General Hospital, Department of Medicine, Harvard Medical School, Boston, MA 02114.
  • Hendren K; Pediatric Surgical Research Laboratories, Massachusetts General Hospital, Department of Surgery, Harvard Medical School, Boston, MA 02114;
  • Coletti CM; Pediatric Surgical Research Laboratories, Massachusetts General Hospital, Department of Surgery, Harvard Medical School, Boston, MA 02114;
  • Yu A; Pediatric Surgical Research Laboratories, Massachusetts General Hospital, Department of Surgery, Harvard Medical School, Boston, MA 02114;
  • Castro CM; Gynecological Oncology, Massachusetts General Hospital, Department of Medicine, Harvard Medical School, Boston, MA 02114.
  • Birrer MJ; Gynecological Oncology, Massachusetts General Hospital, Department of Medicine, Harvard Medical School, Boston, MA 02114.
  • Gao G; Gene Therapy Center, University of Massachusetts Medical School, Worcester, MA 01655;
  • Donahoe PK; Pediatric Surgical Research Laboratories, Massachusetts General Hospital, Department of Surgery, Harvard Medical School, Boston, MA 02114; pdonahoe@partners.org.
Proc Natl Acad Sci U S A ; 112(32): E4418-27, 2015 Aug 11.
Article em En | MEDLINE | ID: mdl-26216943

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Ovarianas / Terapia Genética / Dependovirus / Ensaios Antitumorais Modelo de Xenoenxerto / Hormônio Antimülleriano Tipo de estudo: Prognostic_studies Limite: Adult / Aged / Aged80 / Animals / Female / Humans / Middle aged Idioma: En Ano de publicação: 2015 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Ovarianas / Terapia Genética / Dependovirus / Ensaios Antitumorais Modelo de Xenoenxerto / Hormônio Antimülleriano Tipo de estudo: Prognostic_studies Limite: Adult / Aged / Aged80 / Animals / Female / Humans / Middle aged Idioma: En Ano de publicação: 2015 Tipo de documento: Article