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Pharmacometrics Markup Language (PharmML): Opening New Perspectives for Model Exchange in Drug Development.
Swat, M J; Moodie, S; Wimalaratne, S M; Kristensen, N R; Lavielle, M; Mari, A; Magni, P; Smith, M K; Bizzotto, R; Pasotti, L; Mezzalana, E; Comets, E; Sarr, C; Terranova, N; Blaudez, E; Chan, P; Chard, J; Chatel, K; Chenel, M; Edwards, D; Franklin, C; Giorgino, T; Glont, M; Girard, P; Grenon, P; Harling, K; Hooker, A C; Kaye, R; Keizer, R; Kloft, C; Kok, J N; Kokash, N; Laibe, C; Laveille, C; Lestini, G; Mentré, F; Munafo, A; Nordgren, R; Nyberg, H B; Parra-Guillen, Z P; Plan, E; Ribba, B; Smith, G; Trocóniz, I F; Yvon, F; Milligan, P A; Harnisch, L; Karlsson, M; Hermjakob, H; Le Novère, N.
Afiliação
  • Swat MJ; EMBL-European Bioinformatics Institute, Wellcome Trust Genome Campus Hinxton, Cambridgeshire, UK.
  • Moodie S; Eight Pillars Ltd Edinburgh, UK.
  • Wimalaratne SM; EMBL-European Bioinformatics Institute, Wellcome Trust Genome Campus Hinxton, Cambridgeshire, UK.
  • Kristensen NR; Novo Nordisk A/S Bagsværd, Denmark.
  • Lavielle M; Inria Saclay Paris, France.
  • Mari A; National Research Council, Institute of Biomedical Engineering Padova, Italy.
  • Magni P; Dipartimento di Ingegneria Industriale e dell'Informazione, Università degli Studi di Pavia Pavia, Italy.
  • Smith MK; Global Clinical Pharmacology, Pfizer Sandwich, UK.
  • Bizzotto R; INSERM, IAME, UMR 1137, Paris, France, University Paris Diderot, IAME, UMR 1137 Sorbonne Paris Cité, Paris, France.
  • Pasotti L; Dipartimento di Ingegneria Industriale e dell'Informazione, Università degli Studi di Pavia Pavia, Italy.
  • Mezzalana E; Dipartimento di Ingegneria Industriale e dell'Informazione, Università degli Studi di Pavia Pavia, Italy.
  • Comets E; INSERM, IAME, UMR 1137, Paris, France, University Paris Diderot, IAME, UMR 1137 Sorbonne Paris Cité, Paris, France.
  • Sarr C; Advanced Quantitative Sciences (AQS), Novartis Basel, Switzerland.
  • Terranova N; Merck Institute for Pharmacometrics, Merck Serono Lausanne, Switzerland.
  • Blaudez E; Lixoft Orsay, France.
  • Chan P; Global Clinical Pharmacology, Pfizer Sandwich, UK.
  • Chard J; Mango Solutions Chippenham, Wiltshire, UK.
  • Chatel K; Lixoft Orsay, France.
  • Chenel M; SGS Exprimo NV, Mechelen, Belgium, Clinical Pharmacokinetics and Pharmacometrics, Institut de Recherches Internationales Servier Suresnes, France.
  • Edwards D; Simcyp (a Certara company) Sheffield, UK.
  • Franklin C; CPMS Technology and Development Southall, UK.
  • Giorgino T; National Research Council, Institute of Biomedical Engineering Padova, Italy.
  • Glont M; EMBL-European Bioinformatics Institute, Wellcome Trust Genome Campus Hinxton, Cambridgeshire, UK.
  • Girard P; Merck Institute for Pharmacometrics, Merck Serono Lausanne, Switzerland.
  • Grenon P; CHIME, University College London London, UK.
  • Harling K; Department of Pharmaceutical Biosciences, Uppsala University Uppsala, Sweden.
  • Hooker AC; Department of Pharmaceutical Biosciences, Uppsala University Uppsala, Sweden.
  • Kaye R; Mango Solutions Chippenham, Wiltshire, UK.
  • Keizer R; Department of Pharmaceutical Biosciences, Uppsala University Uppsala, Sweden.
  • Kloft C; Freie Universtitaet Berlin, Germany, Institute of Pharmacy, Department of Clinical Pharmacy and Biochemistry Berlin, Germany.
  • Kok JN; Leiden Institute of Advanced Computer Science (LIACS), Leiden University Leiden, The Netherlands.
  • Kokash N; Leiden Institute of Advanced Computer Science (LIACS), Leiden University Leiden, The Netherlands.
  • Laibe C; EMBL-European Bioinformatics Institute, Wellcome Trust Genome Campus Hinxton, Cambridgeshire, UK.
  • Laveille C; SGS Exprimo NV, Mechelen, Belgium, Clinical Pharmacokinetics and Pharmacometrics, Institut de Recherches Internationales Servier Suresnes, France.
  • Lestini G; INSERM, IAME, UMR 1137, Paris, France, University Paris Diderot, IAME, UMR 1137 Sorbonne Paris Cité, Paris, France.
  • Mentré F; INSERM, IAME, UMR 1137, Paris, France, University Paris Diderot, IAME, UMR 1137 Sorbonne Paris Cité, Paris, France.
  • Munafo A; Merck Institute for Pharmacometrics, Merck Serono Lausanne, Switzerland.
  • Nordgren R; Department of Pharmaceutical Biosciences, Uppsala University Uppsala, Sweden.
  • Nyberg HB; Mango Solutions Chippenham, Wiltshire, UK ; Department of Pharmaceutical Biosciences, Uppsala University Uppsala, Sweden.
  • Parra-Guillen ZP; Freie Universtitaet Berlin, Germany, Institute of Pharmacy, Department of Clinical Pharmacy and Biochemistry Berlin, Germany.
  • Plan E; Department of Pharmaceutical Biosciences, Uppsala University Uppsala, Sweden.
  • Ribba B; Inria Grenoble - Rhône-Alpes Grenoble, France.
  • Smith G; Scientific Computing Group, Cyprotex Discovery Limited Macclesfield, Crewe, UK.
  • Trocóniz IF; Department of Pharmacy and Pharmaceutical Technology, University of Navarra Pamplona, Spain.
  • Yvon F; EMBL-European Bioinformatics Institute, Wellcome Trust Genome Campus Hinxton, Cambridgeshire, UK.
  • Milligan PA; Global Clinical Pharmacology, Pfizer Sandwich, UK.
  • Harnisch L; Global Clinical Pharmacology, Pfizer Sandwich, UK.
  • Karlsson M; Department of Pharmaceutical Biosciences, Uppsala University Uppsala, Sweden.
  • Hermjakob H; EMBL-European Bioinformatics Institute, Wellcome Trust Genome Campus Hinxton, Cambridgeshire, UK.
  • Le Novère N; EMBL-European Bioinformatics Institute, Wellcome Trust Genome Campus Hinxton, Cambridgeshire, UK ; Babraham Institute, Babraham Research Campus Cambridge, UK.
CPT Pharmacometrics Syst Pharmacol ; 4(6): 316-9, 2015 Jun.
Article em En | MEDLINE | ID: mdl-26225259
ABSTRACT
The lack of a common exchange format for mathematical models in pharmacometrics has been a long-standing problem. Such a format has the potential to increase productivity and analysis quality, simplify the handling of complex workflows, ensure reproducibility of research, and facilitate the reuse of existing model resources. Pharmacometrics Markup Language (PharmML), currently under development by the Drug Disease Model Resources (DDMoRe) consortium, is intended to become an exchange standard in pharmacometrics by providing means to encode models, trial designs, and modeling steps.
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2015 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2015 Tipo de documento: Article