Striatal and extrastriatal dopamine release in the common marmoset brain measured by positron emission tomography and [(18)F]fallypride.
Neurosci Res
; 101: 1-5, 2015 Dec.
Article
em En
| MEDLINE
| ID: mdl-26232153
ABSTRACT
Previous studies have demonstrated that patients with schizophrenia show greater sensitivity to psychostimulants than healthy subjects. Sensitization to psychostimulants and resultant alteration of dopaminergic neurotransmission in rodents has been suggested as a useful model of schizophrenia. This study sought to examine the use of methylphenidate as a psychostimulant to induce dopamine release and that of [(18)F]fallypride as a radioligand to quantify the release in a primate model of schizophrenia. Four common marmosets were scanned by positron emission tomography twice, before and after methylphenidate challenge, to evaluate dopamine release. Four other marmosets were sensitized by repeated methamphetamine (MAP) administration. Then, they were scanned twice, before and after methylphenidate challenge, to evaluate whether MAP-sensitization induced greater sensitivity to methylphenidate. We revealed a main effect of the methylphenidate challenge but not the MAP pretreatment on the striatal binding potential. These results suggest that methylphenidate-induced striatal dopamine release in the common marmoset could be evaluated by [(18)F]fallypride.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Esquizofrenia
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Encéfalo
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Callithrix
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Dopamina
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Tomografia por Emissão de Pósitrons
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Modelos Animais de Doenças
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Estimulantes do Sistema Nervoso Central
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Metanfetamina
Limite:
Animals
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article