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Development and validation of an HPLC-MS/MS analytical method for quantitative analysis of TCBA-TPQ, a novel anticancer makaluvamine analog, and application in a pharmacokinetic study in rats.
Yu, Jun-Xian; Voruganti, Sukesh; Li, Dan-Dan; Qin, Jiang-Jiang; Nag, Subhasree; Xu, Su; Velu, Sadanandan E; Wang, Wei; Zhang, Ruiwen.
Afiliação
  • Yu JX; Key Laboratory of Drug Targeting and Drug Delivery System, Ministry of Education, West China School of Pharmacy, Sichuan University, Chengdu 610041, China; Center for Drug Evaluation, China Food and Drug Administration, Beijing 100038, China.
  • Voruganti S; Key Laboratory of Drug Targeting and Drug Delivery System, Ministry of Education, West China School of Pharmacy, Sichuan University, Chengdu 610041, China; China Pharmaceutical University, Nanjing 210009, China.
  • Li DD; Center for Drug Evaluation, China Food and Drug Administration, Beijing 100038, China.
  • Qin JJ; Key Laboratory of Drug Targeting and Drug Delivery System, Ministry of Education, West China School of Pharmacy, Sichuan University, Chengdu 610041, China; China Pharmaceutical University, Nanjing 210009, China.
  • Nag S; Key Laboratory of Drug Targeting and Drug Delivery System, Ministry of Education, West China School of Pharmacy, Sichuan University, Chengdu 610041, China.
  • Xu S; China National Institutes for Food and Drug Control, Beijing 100035, China.
  • Velu SE; China National Institutes for Food and Drug Control, Beijing 100035, China.
  • Wang W; Key Laboratory of Drug Targeting and Drug Delivery System, Ministry of Education, West China School of Pharmacy, Sichuan University, Chengdu 610041, China; China Pharmaceutical University, Nanjing 210009, China. Electronic address: wwei.wang@ttuhsc.edu.
  • Zhang R; Key Laboratory of Drug Targeting and Drug Delivery System, Ministry of Education, West China School of Pharmacy, Sichuan University, Chengdu 610041, China; China Pharmaceutical University, Nanjing 210009, China. Electronic address: ruiwen.zhang@ttuhsc.edu.
Chin J Nat Med ; 13(7): 554-60, 2015 Jul.
Article em En | MEDLINE | ID: mdl-26233847
ABSTRACT
We have recently designed and synthesized several novel iminoquinone anticancer agents that have entered preclinical development for the treatment of human cancers. Herein we developed and validated a quantitative HPLC-MS/MS analytical method for one of the lead novel anticancer makaluvamine analog, TCBA-TPQ, and conducted a pharmacokinetic study in laboratory rats. Our results indicated that the HPLC-MS/MS method was precise, accurate, and specific. Using this method, we carried out in vitro and in vivo evaluations of the pharmacological properties of TCBA-TPQ and plasma pharmacokinetics in rats. Our results provide a basis for future preclinical and clinical development of this promising anticancer marine analog.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pirróis / Cromatografia Líquida de Alta Pressão / Quinolonas / Espectrometria de Massas em Tandem / Antineoplásicos Limite: Animals Idioma: En Ano de publicação: 2015 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pirróis / Cromatografia Líquida de Alta Pressão / Quinolonas / Espectrometria de Massas em Tandem / Antineoplásicos Limite: Animals Idioma: En Ano de publicação: 2015 Tipo de documento: Article