Identification of a DYRK1A Inhibitor that Induces Degradation of the Target Kinase using Co-chaperone CDC37 fused with Luciferase nanoKAZ.

Sonamoto, Rie; Kii, Isao; Koike, Yuka; Sumida, Yuto; Kato-Sumida, Tomoe; Okuno, Yukiko; Hosoya, Takamitsu; Hagiwara, Masatoshi

Sonamoto, Rie; Kii, Isao; Koike, Yuka; Sumida, Yuto; Kato-Sumida, Tomoe; Okuno, Yukiko; Hosoya, Takamitsu; Hagiwara, Masatoshi.

Afiliação

Sonamoto R; 1] Department of Anatomy and Developmental Biology, Graduate School of Medicine, Kyoto University, Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan [2] Laboratory of Functional Biology, Graduate School of Biostudies, Kyoto University, Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan.
Kii I; Department of Anatomy and Developmental Biology, Graduate School of Medicine, Kyoto University, Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan.
Koike Y; Department of Anatomy and Developmental Biology, Graduate School of Medicine, Kyoto University, Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan.
Sumida Y; Laboratory of Chemical Bioscience, Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, 2-3-10 Kanda-Surugadai, Chiyoda-ku, Tokyo 101-0062, Japan.
Kato-Sumida T; Laboratory of Chemical Bioscience, Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, 2-3-10 Kanda-Surugadai, Chiyoda-ku, Tokyo 101-0062, Japan.
Okuno Y; Medical Research Support Center, Graduate School of Medicine, Kyoto University, Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan.
Hosoya T; Laboratory of Chemical Bioscience, Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, 2-3-10 Kanda-Surugadai, Chiyoda-ku, Tokyo 101-0062, Japan.
Hagiwara M; Department of Anatomy and Developmental Biology, Graduate School of Medicine, Kyoto University, Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan.

Sci Rep ; 5: 12728, 2015 Aug 03.

Article em En | MEDLINE | ID: mdl-26234946

Assuntos

Proteínas de Ciclo Celular/genética; Chaperoninas/genética; Avaliação Pré-Clínica de Medicamentos/métodos; Luciferases/genética; Inibidores de Proteínas Quinases/farmacologia; Proteínas Serina-Treonina Quinases/antagonistas & inibidores; Proteínas Tirosina Quinases/antagonistas & inibidores; Benzofuranos/farmacologia; Proteínas de Ciclo Celular/metabolismo; Chaperoninas/metabolismo; Células HEK293; Proteínas de Choque Térmico HSP90/genética; Proteínas de Choque Térmico HSP90/metabolismo; Humanos; Luciferases/metabolismo; Chaperonas Moleculares/genética; Mutação; Proteínas Serina-Treonina Quinases/genética; Proteínas Serina-Treonina Quinases/metabolismo; Proteínas Tirosina Quinases/genética; Proteínas Tirosina Quinases/metabolismo; Proteínas Recombinantes de Fusão/genética; Proteínas Recombinantes de Fusão/metabolismo; Bibliotecas de Moléculas Pequenas/farmacologia; Tiazolidinas/farmacologia; Triazóis/farmacologia; Quinases Dyrk

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas Tirosina Quinases / Proteínas Serina-Treonina Quinases / Chaperoninas / Proteínas de Ciclo Celular / Inibidores de Proteínas Quinases / Avaliação Pré-Clínica de Medicamentos / Luciferases Tipo de estudo: Diagnostic_studies Limite: Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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