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Abnormal perfusion in patellofemoral subchondral bone marrow in the rat anterior cruciate ligament transection model of post-traumatic osteoarthritis: a dynamic contrast-enhanced magnetic resonance imaging study.
Tsai, P-H; Lee, H-S; Siow, T Y; Wang, C-Y; Chang, Y-C; Lin, M-H; Hsu, Y-C; Lee, C-H; Chung, H-W; Huang, G-S.
Afiliação
  • Tsai PH; Department of Radiology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, ROC; Department of Radiology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan, ROC; Department of Medical Imaging and Translational Imaging Research Center, Taip
  • Lee HS; Department of Pathology and Laboratory Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan, ROC; Department of Pathology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, ROC.
  • Siow TY; Department of Medical Imaging and Intervention, Chang Gung Memorial Hospital at Linkou, Institute for Radiological Research, College of Medicine, Chang Gung University, Taoyuan, Taiwan, ROC; Institute of Biomedical Sciences, Academic Sinica, Taipei, Taiwan, ROC.
  • Wang CY; Department of Radiology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, ROC; Department and Graduate Institute of Biology and Anatomy, National Defense Medical Center, Taipei, Taiwan, ROC.
  • Chang YC; Department of Mathematics, Tamkang University, Taipei, Taiwan, ROC.
  • Lin MH; Institute of Biomedical Sciences, Academic Sinica, Taipei, Taiwan, ROC.
  • Hsu YC; Department of Radiology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, ROC.
  • Lee CH; Department of Orthopedics, School of Medicine, College of Medicine, Taipei Medical University and Hospital, Taipei, Taiwan, ROC.
  • Chung HW; Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei, Taiwan, ROC.
  • Huang GS; Department of Radiology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, ROC; Department of Medical Research, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, ROC. Electronic address: gsh5@seed.net.tw.
Osteoarthritis Cartilage ; 24(1): 129-33, 2016 Jan.
Article em En | MEDLINE | ID: mdl-26241778
OBJECTIVE: Although anterior cruciate ligament (ACL) injury is a well-recognized risk factor for developing knee post-traumatic osteoarthritis (PTOA), the process in the patellofemoral (PF) joint after ACL injury is still under-researched. Our aim was to investigate the perfusion changes in PF subchondral bone marrow in the rat ACL transection (ACLX) model of PTOA using dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). DESIGN: Eighteen male Sprague Dawley rats were randomly separated into three groups (n = 6 each group): a normal control group and groups receiving ACLX and sham-surgery, respectively, in the right knee. Perfusion parameters in the patellar and femoral subchondral bone marrows of all rats were measured on DCE-MRI at 0, 4, 8, and 16 weeks after respective treatment. After the last MRI at week 16, the rats were sacrificed and their right knees were harvested for histologic examination. In addition, to observe the long-term histologic change in PF joints, 9 additional rats (n = 3 in each group) were included and sacrificed at week 32 for histologic examination. RESULTS: In the ACLX group vs the sham and control groups, the perfusion parameters were significantly changed in both patellar and femoral subchondral bone marrows at week 16. Histologic examination revealed cartilage defects in ACLX rats at 32 weeks after surgery. CONCLUSIONS: These data point to a possible functional relationship between subchondral bone marrow perfusion abnormalities and cartilage breakdown in PTOA. Moreover, the perfusion parameters derived from DCE-MRI can potentially serve as biomarkers of early OA.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Patela / Medula Óssea / Osteoartrite do Joelho / Fêmur / Lesões do Ligamento Cruzado Anterior Tipo de estudo: Etiology_studies / Prognostic_studies / Risk_factors_studies Limite: Animals Idioma: En Ano de publicação: 2016 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Patela / Medula Óssea / Osteoartrite do Joelho / Fêmur / Lesões do Ligamento Cruzado Anterior Tipo de estudo: Etiology_studies / Prognostic_studies / Risk_factors_studies Limite: Animals Idioma: En Ano de publicação: 2016 Tipo de documento: Article