Peptide δ-Turn: Literature Survey and Recent Progress.
Chemistry
; 21(40): 13866-77, 2015 Sep 28.
Article
em En
| MEDLINE
| ID: mdl-26243713
ABSTRACT
Among the various types of α-peptide folding motifs, δ-turn, which requires a central cis-amide disposition, has been one of the least extensively investigated. In particular, this main-chain reversal topology has been studied in-depth neither in linear/cyclic peptides nor in proteins. This Minireview article assembles and critically analyzes relevant data from a literature survey on the δ-turn conformation in those compounds. Unpublished results from recent conformational energy calculations and a preliminary solution-state analysis on a small model peptide, currently ongoing in our laboratories, are also briefly outlined.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Peptídeos
/
Peptídeos Cíclicos
/
Proteínas
Tipo de estudo:
Qualitative_research
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article