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Lab-on-Chip-Based Platform for Fast Molecular Diagnosis of Multidrug-Resistant Tuberculosis.
Cabibbe, Andrea M; Miotto, Paolo; Moure, Raquel; Alcaide, Fernando; Feuerriegel, Silke; Pozzi, Gianni; Nikolayevskyy, Vladislav; Drobniewski, Francis; Niemann, Stefan; Reither, Klaus; Cirillo, Daniela M.
Afiliação
  • Cabibbe AM; Emerging Bacterial Pathogens Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy.
  • Miotto P; Emerging Bacterial Pathogens Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy.
  • Moure R; Servei de Microbiologia, Hospital Universitari de Bellvitge-IDIBELL, Universitat de Barcelona, Barcelona, Spain.
  • Alcaide F; Servei de Microbiologia, Hospital Universitari de Bellvitge-IDIBELL, Universitat de Barcelona, Barcelona, Spain.
  • Feuerriegel S; Molecular Mycobacteriology, Research Center Borstel, Borstel, Germany.
  • Pozzi G; Laboratory of Molecular Microbiology and Biotechnology, Department of Medical Biotechnologies, University of Siena, Siena, Italy.
  • Nikolayevskyy V; Clinical TB and HIV Group, Blizard Institute, Queen Mary University of London, London, United Kingdom Department of Infectious Diseases and Immunity, Imperial College London, London, United Kingdom.
  • Drobniewski F; Clinical TB and HIV Group, Blizard Institute, Queen Mary University of London, London, United Kingdom Department of Infectious Diseases and Immunity, Imperial College London, London, United Kingdom.
  • Niemann S; Molecular Mycobacteriology, Research Center Borstel, Borstel, Germany.
  • Reither K; Swiss Tropical and Public Health Institute, Basel, Switzerland Ifakara Health Institute, Bagamoyo, United Republic of Tanzania.
  • Cirillo DM; Emerging Bacterial Pathogens Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy cirillo.daniela@hsr.it.
J Clin Microbiol ; 53(12): 3876-80, 2015 Dec.
Article em En | MEDLINE | ID: mdl-26246486
ABSTRACT
We evaluated the performance of the molecular lab-on-chip-based VerePLEX Biosystem for detection of multidrug-resistant tuberculosis (MDR-TB), obtaining a diagnostic accuracy of more than 97.8% compared to sequencing and MTBDRplus assay for Mycobacterium tuberculosis complex and rifampin and isoniazid resistance detection on clinical isolates and smear-positive specimens. The speed, user-friendly interface, and versatility make it suitable for routine laboratory use.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tuberculose Resistente a Múltiplos Medicamentos / Técnicas de Diagnóstico Molecular / Dispositivos Lab-On-A-Chip Tipo de estudo: Diagnostic_studies / Evaluation_studies Limite: Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tuberculose Resistente a Múltiplos Medicamentos / Técnicas de Diagnóstico Molecular / Dispositivos Lab-On-A-Chip Tipo de estudo: Diagnostic_studies / Evaluation_studies Limite: Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article