Carbon nanotubes supported tyrosinase in the synthesis of lipophilic hydroxytyrosol and dihydrocaffeoyl catechols with antiviral activity against DNA and RNA viruses.
Bioorg Med Chem
; 23(17): 5345-51, 2015 Sep 01.
Article
em En
| MEDLINE
| ID: mdl-26260341
ABSTRACT
Hydroxytyrosol and dihydrocaffeoyl catechols with lipophilic properties have been synthesized in high yield using tyrosinase immobilized on multi-walled carbon nanotubes by the Layer-by-Layer technique. All synthesized catechols were evaluated against a large panel of DNA and RNA viruses, including Poliovirus type 1, Echovirus type 9, Herpes simplex virus type 1 (HSV-1), Herpes simplex virus type 2 (HSV-2), Coxsackievirus type B3 (Cox B3), Adenovirus type 2 and type 5 and Cytomegalovirus (CMV). A significant antiviral activity was observed in the inhibition of HSV-1, HSV-2, Cox B3 and CMV. The mechanism of action of the most active dihydrocaffeoyl derivative was investigated against a model of HSV-1 infection.
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Base de dados:
MEDLINE
Assunto principal:
Antivirais
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Vírus de RNA
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Catecóis
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Vírus de DNA
Limite:
Humans
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article