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A recent epidemiological cluster of acute hepatitis B genotype F1b infection in a restricted geographical area of Italy.
Pollicita, M; Alteri, C; Bellocchi, M C; Armenia, D; Carioti, L; Salpini, R; Colagrossi, L; Battisti, A; Aragri, M; Fabeni, L; Mariani, R; Dalessandro, M; Ranelli, A; Paoloni, M; Parruti, G; Perno, C F; Svicher, V.
Afiliação
  • Pollicita M; Department of Experimental Medicine and Surgery, University of Rome Tor Vergata, Rome, Italy.
  • Alteri C; Department of Experimental Medicine and Surgery, University of Rome Tor Vergata, Rome, Italy.
  • Bellocchi MC; Department of Experimental Medicine and Surgery, University of Rome Tor Vergata, Rome, Italy.
  • Armenia D; Department of Experimental Medicine and Surgery, University of Rome Tor Vergata, Rome, Italy.
  • Carioti L; Department of Experimental Medicine and Surgery, University of Rome Tor Vergata, Rome, Italy.
  • Salpini R; Department of Experimental Medicine and Surgery, University of Rome Tor Vergata, Rome, Italy.
  • Colagrossi L; Department of Experimental Medicine and Surgery, University of Rome Tor Vergata, Rome, Italy.
  • Battisti A; Department of Experimental Medicine and Surgery, University of Rome Tor Vergata, Rome, Italy.
  • Aragri M; Department of Experimental Medicine and Surgery, University of Rome Tor Vergata, Rome, Italy.
  • Fabeni L; INMI 'L. Spallanzani', Rome, Italy.
  • Mariani R; 'S. S. Filippo e Nicola' Hospital, Infectious Disease Unit, Avezzano, Italy.
  • Dalessandro M; 'S. S. Filippo e Nicola' Hospital, Infectious Disease Unit, Avezzano, Italy.
  • Ranelli A; 'S. S. Filippo e Nicola' Hospital, Infectious Disease Unit, Avezzano, Italy.
  • Paoloni M; 'S. S. Filippo e Nicola' Hospital, Infectious Disease Unit, Avezzano, Italy.
  • Parruti G; 'Spirito Santo' Hospital, Infectious Disease Unit, Pescara, Italy.
  • Perno CF; Department of Experimental Medicine and Surgery, University of Rome Tor Vergata, Rome, Italy.
  • Svicher V; Department of Experimental Medicine and Surgery, University of Rome Tor Vergata, Rome, Italy. Electronic address: valentina.svicher@uniroma2.it.
Clin Microbiol Infect ; 21(12): 1124.e1-4, 2015 Dec.
Article em En | MEDLINE | ID: mdl-26260987
ABSTRACT
In this study, by phylogenetic analysis, we identified an epidemiological cluster involving eight individuals diagnosed with acute hepatitis B virus (HBV) infection related to unprotected sexual intercourse in a restricted area of central Italy (time period 2011-2014). Notably, these patients (six of eight Italians) were infected by subgenotype F1b, which is not commonly found in western countries. Ultra-deep pyrosequencing confirmed a superimposable composition of HBV quasi-species in these patients. Despite the availability of effective vaccination, this study highlights the importance of not underestimating the risk of HBV infection, of continuing to set up surveillance programmes for HBV infection, and of investigating the pathogenetic potential of these atypical genotypes.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Vírus da Hepatite B / Hepatite B Limite: Adult / Female / Humans / Male / Middle aged País como assunto: Europa Idioma: En Ano de publicação: 2015 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Vírus da Hepatite B / Hepatite B Limite: Adult / Female / Humans / Male / Middle aged País como assunto: Europa Idioma: En Ano de publicação: 2015 Tipo de documento: Article