Antitumor Effects and Related Mechanisms of Penicitrinine A, a Novel Alkaloid with a Unique Spiro Skeleton from the Marine Fungus Penicillium citrinum.

Liu, Qin-Ying; Zhou, Tong; Zhao, Yang-Yang; Chen, Li; Gong, Mei-Wei; Xia, Qi-Wen; Ying, Min-Gang; Zheng, Qiu-Hong; Zhang, Qi-Qing

Liu, Qin-Ying; Zhou, Tong; Zhao, Yang-Yang; Chen, Li; Gong, Mei-Wei; Xia, Qi-Wen; Ying, Min-Gang; Zheng, Qiu-Hong; Zhang, Qi-Qing.

Afiliação

Liu QY; Institute of Biomedical and Pharmaceutical Technology, Fuzhou University, Fuzhou 350002, China. yingmg@163.com.
Zhou T; Fujian Provincial Key Laboratory of Tumor Biotherapy, Fujian Provincial Tumor Hospital, Fuzhou 350014, China. yingmg@163.com.
Zhao YY; Institute of Biomedical and Pharmaceutical Technology, Fuzhou University, Fuzhou 350002, China. vickychou90220@163.com.
Chen L; Institute of Biomedical and Pharmaceutical Technology, Fuzhou University, Fuzhou 350002, China. zhaoyangyang0929@163.com.
Gong MW; Institute of Biomedical and Pharmaceutical Technology, Fuzhou University, Fuzhou 350002, China. ibptcl@fzu.edu.cn.
Xia QW; Institute of Biomedical and Pharmaceutical Technology, Fuzhou University, Fuzhou 350002, China. 742946642@qq.com.
Ying MG; Institute of Biomedical and Pharmaceutical Technology, Fuzhou University, Fuzhou 350002, China. xiaqiwen0917@163.com.
Zheng QH; Fujian Provincial Key Laboratory of Tumor Biotherapy, Fujian Provincial Tumor Hospital, Fuzhou 350014, China. yingmg@163.com.
Zhang QQ; Fujian Provincial Key Laboratory of Tumor Biotherapy, Fujian Provincial Tumor Hospital, Fuzhou 350014, China. zqh2858@foxmail.com.

Mar Drugs ; 13(8): 4733-53, 2015 Jul 31.

Article em En | MEDLINE | ID: mdl-26264002

Assuntos

Alcaloides/farmacologia; Antineoplásicos/farmacologia; Organismos Aquáticos/metabolismo; Penicillium/metabolismo; Apoptose/efeitos dos fármacos; Linhagem Celular Tumoral; Proliferação de Células/efeitos dos fármacos; Humanos; Metaloproteinase 9 da Matriz/metabolismo; Melanoma/tratamento farmacológico; Melanoma/metabolismo; Proteínas Proto-Oncogênicas c-bcl-2/metabolismo; Inibidor Tecidual de Metaloproteinase-1/metabolismo; Proteína X Associada a bcl-2/metabolismo

Palavras-chave

anti-metastatic; anticancer activity; apoptosis; human malignant melanoma cell A-375; marine-derived fungus; penicitrinine A

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Penicillium / Alcaloides / Organismos Aquáticos / Antineoplásicos Limite: Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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