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Antimalarial benzoheterocyclic 4-aminoquinolines: Structure-activity relationship, in vivo evaluation, mechanistic and bioactivation studies.
Ongarora, Dennis S B; Strydom, Natasha; Wicht, Kathryn; Njoroge, Mathew; Wiesner, Lubbe; Egan, Timothy J; Wittlin, Sergio; Jurva, Ulrik; Masimirembwa, Collen M; Chibale, Kelly.
Afiliação
  • Ongarora DS; Department of Chemistry, University of Cape Town, Rondebosch 7701, South Africa; South African Medical Research Council Drug Discovery and Development Research Unit, University of Cape Town, Rondebosch 7701, South Africa; Department of Pharmaceutical Chemistry, University of Nairobi, Nairobi, Kenya.
  • Strydom N; Department of Chemistry, University of Cape Town, Rondebosch 7701, South Africa.
  • Wicht K; Department of Chemistry, University of Cape Town, Rondebosch 7701, South Africa.
  • Njoroge M; Department of Chemistry, University of Cape Town, Rondebosch 7701, South Africa; South African Medical Research Council Drug Discovery and Development Research Unit, University of Cape Town, Rondebosch 7701, South Africa.
  • Wiesner L; Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Observatory 7925, South Africa.
  • Egan TJ; Department of Chemistry, University of Cape Town, Rondebosch 7701, South Africa.
  • Wittlin S; Swiss Tropical and Public Health Institute, Socinstrasse 57, 4002 Basel, Switzerland; University of Basel, Socinstrasse 57, 4002 Basel, Switzerland.
  • Jurva U; AstraZeneca R&D, Mölndal, Sweden.
  • Masimirembwa CM; African Institute of Biomedical Science and Technology, Zimbabwe.
  • Chibale K; Department of Chemistry, University of Cape Town, Rondebosch 7701, South Africa; Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Rondebosch 7701, South Africa; South African Medical Research Council Drug Discovery and Development Research Unit, University of Cape Tow
Bioorg Med Chem ; 23(17): 5419-32, 2015 Sep 01.
Article em En | MEDLINE | ID: mdl-26264839
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Plasmodium berghei / Plasmodium falciparum / Aminoquinolinas / Malária / Antimaláricos Limite: Animals / Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Plasmodium berghei / Plasmodium falciparum / Aminoquinolinas / Malária / Antimaláricos Limite: Animals / Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article