NMR structural characterization of the N-terminal active domain of the gyrase B subunit from Pseudomonas aeruginosa and its complex with an inhibitor.

Li, Yan; Wong, Yun Xuan; Poh, Zhi Ying; Wong, Ying Lei; Lee, Michelle Yueqi; Ng, Hui Qi; Liu, Boping; Hung, Alvin W; Cherian, Joseph; Hill, Jeffrey; Keller, Thomas H; Kang, CongBao

Li, Yan; Wong, Yun Xuan; Poh, Zhi Ying; Wong, Ying Lei; Lee, Michelle Yueqi; Ng, Hui Qi; Liu, Boping; Hung, Alvin W; Cherian, Joseph; Hill, Jeffrey; Keller, Thomas H; Kang, CongBao.

Afiliação

Li Y; Experimental Therapeutics Centre, Agency for Science, Technology and Research (A*STAR), 31 Biopolis Way, Nanos, #03-01, Singapore 138669, Singapore.
Wong YX; Experimental Therapeutics Centre, Agency for Science, Technology and Research (A*STAR), 31 Biopolis Way, Nanos, #03-01, Singapore 138669, Singapore.
Poh ZY; Experimental Therapeutics Centre, Agency for Science, Technology and Research (A*STAR), 31 Biopolis Way, Nanos, #03-01, Singapore 138669, Singapore.
Wong YL; Experimental Therapeutics Centre, Agency for Science, Technology and Research (A*STAR), 31 Biopolis Way, Nanos, #03-01, Singapore 138669, Singapore.
Lee MY; Experimental Therapeutics Centre, Agency for Science, Technology and Research (A*STAR), 31 Biopolis Way, Nanos, #03-01, Singapore 138669, Singapore.
Ng HQ; Experimental Therapeutics Centre, Agency for Science, Technology and Research (A*STAR), 31 Biopolis Way, Nanos, #03-01, Singapore 138669, Singapore.
Liu B; Experimental Therapeutics Centre, Agency for Science, Technology and Research (A*STAR), 31 Biopolis Way, Nanos, #03-01, Singapore 138669, Singapore.
Hung AW; Experimental Therapeutics Centre, Agency for Science, Technology and Research (A*STAR), 31 Biopolis Way, Nanos, #03-01, Singapore 138669, Singapore.
Cherian J; Experimental Therapeutics Centre, Agency for Science, Technology and Research (A*STAR), 31 Biopolis Way, Nanos, #03-01, Singapore 138669, Singapore.
Hill J; Experimental Therapeutics Centre, Agency for Science, Technology and Research (A*STAR), 31 Biopolis Way, Nanos, #03-01, Singapore 138669, Singapore.
Keller TH; Experimental Therapeutics Centre, Agency for Science, Technology and Research (A*STAR), 31 Biopolis Way, Nanos, #03-01, Singapore 138669, Singapore.
Kang C; Experimental Therapeutics Centre, Agency for Science, Technology and Research (A*STAR), 31 Biopolis Way, Nanos, #03-01, Singapore 138669, Singapore. Electronic address: cbkang@etc.a-star.edu.sg.

FEBS Lett ; 589(19 Pt B): 2683-9, 2015 Sep 14.

Article em En | MEDLINE | ID: mdl-26272827

Assuntos

Domínio Catalítico; DNA Girase/química; DNA Girase/metabolismo; Pseudomonas aeruginosa/enzimologia; Inibidores da Topoisomerase II/metabolismo; Trifosfato de Adenosina/metabolismo; Sequência de Aminoácidos; Modelos Moleculares; Dados de Sequência Molecular; Ressonância Magnética Nuclear Biomolecular; Ligação Proteica; Inibidores da Topoisomerase II/química; Inibidores da Topoisomerase II/farmacologia; Ureia/química; Ureia/metabolismo; Ureia/farmacologia

Palavras-chave

Drug discovery; Gyrase B; NMR; Structure-based drug design; Topoisomerase

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pseudomonas aeruginosa / Domínio Catalítico / DNA Girase / Inibidores da Topoisomerase II Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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