Cellular mechanisms of MR regulation of adipose tissue physiology and pathophysiology.
J Mol Endocrinol
; 55(2): R1-10, 2015 Oct.
Article
em En
| MEDLINE
| ID: mdl-26272942
ABSTRACT
In addition to the well-documented expression and activity of the mineralocorticoid receptor (MR) in the kidney, in the last decade research on MR has also revealed its important role in regulating functions of extrarenal tissues, including adipose tissue, where MR is involved in adipocyte fundamental processes such as differentiation, autophagy and adipokine secretion. MR expression is increased in adipose tissue of murine models of obesity and in obese human subjects, suggesting that over-activation of the mineralocorticoid signaling leads to dysfunctional adipocyte and associated metabolic disorders. Notably, pharmacological blockade of MR prevents metabolic dysfunctions observed in obese mice and suggests a potential therapeutic use of MR antagonists in the treatment of obesity and metabolic syndrome. However, the molecular pathways affected by MR blockade have been poorly investigated. This review summarizes the functions of MR in the adipocyte, discusses potential signaling pathways mediating MR action, and describes post-translational modifications regulating its activity.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Tecido Adiposo
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Receptores de Mineralocorticoides
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Adipócitos
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Adipogenia
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Obesidade
Limite:
Animals
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article